Now showing items 11-20 of 100
Discriminative stimulus effects of pentobarbital in rhesus monkeys: Tests of stimulus generalization and duration of action
(Springer-Verlag, 1982-02)
Rhesus monkeys were trained to emit 20 or 30 consecutive responses on one lever following an IM injection of pentobarbital (10 or 18 mg/kg) and the same number of consecutive responses on another lever following an injection ...
Comparison of opioid agonists in maintaining responding and in suppressing morphine withdrawal in rhesus monkeys
(Springer-Verlag, 1981-09)
Sixteen opioid agonists were studied for their capacity both to maintain responding previously reinforced by codeine and to suppress the withdrawal syndrome induced by morphine deprivation in rhesus monkeys. All compounds, ...
Anticonvulsant effects of mu (DAGO) and delta (DPDPE) enkephalins in rats
(Elsevier, 1988)
The effects of highly selective mu and delta opioid peptide agonists were determined in two rat models of experimentally-induced convulsions, the flurothyl threshold test and the maximal electroshock test. Intracerebroventricular ...
Postnatal development of beta-endorphin immunoreactivity in the medulla oblongata of rat
(Elsevier, 1985-02)
Beta-endorphin (B-END) like immunoreactivity (i.r.) levels were measured by radioimmunoassay in the medulla oblongata of developing rats on postnatal ages P1-P42 at 7 day intervals, and in adult rats. From P1 to P42, B-END ...
Some thoughts on the relations between animal and human drug-taking
(Elsevier, 1983)
1. 1. Results of studies of drug self-administration have frequently been suggested as indicators of the potential for abuse of these drugs by humans. Historical data (pre 1970), although scant, supported this suggestion ...
A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats
(Springer-Verlag, 1987-09)
Directly observable behavioral effects of the N-methyl- D -aspartate (NMDA) receptor antagonist 2-amino-5-phosphonovalerate (AP5) (10–1,000 mg/kg IP, 0.18–5.6 μmol/rat ICV) and of phencyclidine (PCP) (3.2–56 mg/kg IP, ...
Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons
(Springer-Verlag, 1985-03)
Six pigeons, trained to peck a response key on a fixed-ratio 20 schedule of food reinforcement, were used to examine the effects of morphine, naltrexone, and dextrorphan, before, during, and after chronic treatment with ...
Dynorphin reduces voltage-dependent calcium conductance of mouse dorsal root ganglion neurons
(Elsevier, 1984-12)
Dynorphin A (DYN) (1 [mu]M) decreased somatic calcium-dependent action potential (CAP) duration of a portion of dorsal root ganglion (DRG) neurons in a naloxone reversible manner. Responses to DYN differed from responses ...
Lithium and the structure of exploratory behavior in the rat
(Elsevier, 1980)
1. 1. Adult male Sprague Dawley rats were given lithium as a dietary supplement, or a control diet.2. 2. A single seven hour test of exploratory behavior was carried out after one week of chronic drug exposure.3. 3. The ...
Grooming elicited by intracerebroventricular bombesin and eledoisim in the mouse
(Elsevier, 1980-01)
The behavioral effects of centrally administered bombesin and eledolsin were investigated in the mouse. Both peptides produced syndromes of compulsive stereotyped grooming. Manipulations known to affect other forms of ...