Now showing items 31-40 of 100
Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats
(Springer-Verlag, 1984-12)
Factors influencing the behavioral sensitization (“reverse tolerance”) produced by intermittent amphetamine (AMPH) injections were studied by quantifying rotational behavior in rats that had a unilateral 6-hydroxydopamine ...
Steady state levels of pro-dynorphin-related end products in the striatum and substantia nigra of the adult rhesus monkey
(Elsevier, 1985)
Analysis of an acid extract of the striatum of the rhesus monkey revealed that the molar ratio of dynorphin A(1-8)-sized material and dynorphin (A(1-17)-sized material is approximately 1:1. In addition, the molar ratios ...
Effect of ethanol and of noise on reaction time in the monkey: Variation with stimulus level
(Springer-Verlag, 1980-06)
To determine whether the latency-increasing effects of ethanol were differential with respect to the intensity of the stimulus that initiated the response, three rhesus monkeys were trained on a behavioral task in which ...
Glutamate transmission and toxicity in alzheimer's disease
(Elsevier, 1988)
1. 1. Despite intensive research, the cause of Alzheimer's disease is unknown.2. 2. Glutamate is the major excitatory transmitter of the cerebral cortex and hippocampus and it appears to have an important role in learning ...
Changes occur in central adrenoreceptor function following long-term morphine treatment and during morphine withdrawal
(Elsevier, 1984-12)
Radioloigand binding techniques were used in combination with electrophysiological recording to characterize changes in beta adrenoreceptor activity in various brain areas in rats treated chronically with morphine. Following ...
Fever and leukocytosis: Physical manifestations of bipolar affective disorder?
(Elsevier, 1988)
1. 1. Fever and leukocytosis are occasionally observed in patients with psychiatric disorders. A thorough medical evaluation does not always reveal the origin of these abnormalities.2. 2. We report the case histories of ...
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens
(Elsevier, 1984-12)
The selectivity and relative potencics of opiate receptor antagonists were compared on the mouse vas deferens preparation. ICI-174864 was found to be a highly selective antagonist at delta opiate receptors equal in potency ...
Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy
(Elsevier, 1983)
1. 1. Specific binding of 3H-clonidine to alpha2 adrenoreceptors upon human blood platelet membranes is increased in patients with major depressive disorder (endogenous depression).2. 2. Specific binding of 3H-yohimbine ...
The distribution of cholecystokinin and vasoactive intestinal peptide in rhesus monkey brain as determined by radioimmunoassay
(Elsevier, 1983-07)
The concentration of cholecystokinin (CCK) and vasoactive intestinal peptide (VIP) in dissected cortical and subcortical areas of four rhesus monkeys' brains was determined by radioimmunoassay (RIA). Cerebral cortical ...
Behavioral effects of dynorphin1-13 in the mouse and rat: Initial observations
(Elsevier, 1980)
Dynorphin is a recently identified, pharmacologically potent endogenous opioid peptide. Heretofore it has not been characterized for its behavioral effects. The effects of centrally infused dynorphin upon a variety of ...