Now showing items 51-60 of 100
Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level
(Springer-Verlag, 1987-09)
Acute administration of mecamylamine, a centrally active nicotinic cholinergic agonist, has been shown to increase amount of smoking as indicated by smoking topography (e.g., puff rate, puff duration), expired carbon ...
Development of the catecholamine innervation of the supraoptic nucleus in the Brattleboro rat
(Elsevier, 1984)
The ontogenetic development of the noradrenergic innervation of the supraoptic nucleus was studied in the Brattleboro rat at late postcoital and early postnatal ages. This genetic mutant offers a useful model for analysis ...
Cholinergic properties of desipramine and amoxapine: Assessment using a thermoregulation paradigm
(Elsevier, 1987)
1. 1. The withdrawal of tricyclic antidepressants (TCAs) produces symptoms suggesting cholinergic rebound.2. 2. Amitriptyline (AMI), the most potent antimuscarinic agent among this class of drugs, produces supersensitivity ...
Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon
(Springer-Verlag, 1981-05)
Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding ...
Comparison of acute and chronic lithium treatment on 3 H-norepinephrine uptake by rat brain slices
(Springer-Verlag, 1980-01)
The effects of lithium chloride, given IP in high (2.5–15 mEq/kg) and low (1.25 mEq/kg) doses twice daily, upon 3 H-norepinephrine uptake and retention were examined with slices from four regions of the rat brain, namely ...
The suppression of deprivation and antagonist-induced withdrawal in morphine-dependent rhesus monkeys
(Elsevier, 1984-12)
The capacity of morphine to suppress natural and precipitated withdrawal was compared in morphine-dependent rhesus monkeys. A similar severity of withdrawal was induced by 14-hr deprivation or precipitated by naloxone, ...
The effects of antidepressants on the retention and metabolism of [3H]-norepinephrine in rat brain slices
(Elsevier, 1981-04)
Tricylic antidepressants acutely decrease the neuronal retention of [3H]-norepinehrine ([3H]-NE) by blocking neuronal membrane uptake and/or vesicular uptake and binding. To distinguish between effects upon the plasma ...
Analysis of opioid and non-opioid end products of pro-dynorphin in the substantia nigra of the rat
(Elsevier, 1985-02)
The substantia nigra is among the richest pro-dynorphin terminal field regions in the rat brain. We therefore contrasted processing in this area to the known processing in the posterior pituitary. Fractionation of acid ...
Interaction of synthetic opioid metenkephalin peptide analogs, lilly 127623 and FK 33-824 with indole hallucinogens: Antagonism of N,N-dimethyltryptamine- and LSD-induced disruption of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1983-07)
The selected opioid metenkephalin synthetic peptide analogs Lilly (LY) 127623 and FK 33-824 were tested for behavioral dose effects and potential interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 ...
In situ hybridization histochemistry with synthetic oligonucleotides: Strategies and methods
(Elsevier, 1985)
In situ hybridization histochemistry is a useful method for localizing specific mRNA and studying the regulation of gene expression in an anatomical context. Previously, classical recombinant DNA and microbiological ...