Now showing items 61-70 of 100
Role of serotonergic mechanisms in animal models of predation
(Elsevier, 1980)
1. 1. A short critical review of the role of serotonin in predatory attack is given.2. 2. Among factors determining the degree and type of psychopharmacological involvement are: species, drug, and dependent behavioral ...
Effects of selected opioid agonists and antagonists on DMT-and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1981-11)
Several opioid agonists and antagonists interact with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement, fixed ratio 4 (FR 4 ) behavioral ...
Coupling of multiple opioid receptors to GTPase following selective receptor alkylation in brain membranes
(Elsevier, 1987-12)
Opioid agonists of the mu, kappa and delta types stimulated low-Km guanosine triphosphatase (GTPase) in membranes, from the brain of the rat by up to 34%, with potencies the rank order of which corresponded to the respective ...
Fluphenazine-induced acute and tardive dyskinesias in monkeys
(Springer-Verlag, 1984-09)
Five Cebus apella monkeys were treated with biweekly injections of fluphenazine enanthate (0.1–3.2 mg/kg IM). Three of these completed 1 full year of treatment, one injured its leg after 6 months of treatment and was killed, ...
MSG effects on beta-endorphin and alpha-MSH in the hypothalamus and caudal medulla
(Elsevier, 1988)
Monosodium glutamate (MSG) was given to neonatal male rats to determine its effects on neurons containing beta-endorphin ([beta]-END) and alpha-melanocyte stimulating hormone ([alpha]-MSH) within the basal hypothalamus ...
Anatomical and biochemical studies of the opioid peptides and related substances in the brain
(Elsevier, 1980)
It is now clear that there are at least four opioid peptide-neuronal systems in mammalian brain: the enkephalins, beta-endorphin and dynorphin. The focus of this presentation will be twofold--to focus on the multiple ...
Effects of clonidine and morphine on opioid withdrawal in rhesus monkeys
(Springer-Verlag, 1986-03)
Rhesus monkeys undergoing opioid withdrawal either due to withholding morphine administration for 14 h or due to administration of naloxone, were treated with either morphine or clonidine. Morphine eliminated all of the ...
Combined autoradiographic-immunocytochemical analysis of opioid receptors and opioid peptide neuronal systems in brain
(Elsevier, 1985)
Using adjacent section autoradiography-immunocytochemistry, the distribution of [3H]naloxone binding sites was studied in relation to neuronal systems containing [Leu]enkephalin, dynorphin A, or [beta]-endorphin immunoreactivity ...
Changes in releasability of ACTH and Beta-endorphin with chronic stress
(Elsevier, 1985-02)
The activation of the hypothalamic pituitary adrenal axis by stress is well-known. Using inescapable intermittent footshock as a stressor in rats, we have previously demonstrated a rise in circulating plasma Beta-endorph ...
Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP
(Springer-Verlag, 1987-12)
Pigeons were trained to discriminate either a fixed dose of PCP (1 mg/kg; n =3) or a progressively decreasing dose (1-0.56–0.32 mg/kg; n =4) from saline. Lowering of the training dose shifted the dose-effect curve for PCP's ...