Now showing items 21-30 of 62
Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats
(Springer-Verlag, 1984-12)
Factors influencing the behavioral sensitization (“reverse tolerance”) produced by intermittent amphetamine (AMPH) injections were studied by quantifying rotational behavior in rats that had a unilateral 6-hydroxydopamine ...
Effect of ethanol and of noise on reaction time in the monkey: Variation with stimulus level
(Springer-Verlag, 1980-06)
To determine whether the latency-increasing effects of ethanol were differential with respect to the intensity of the stimulus that initiated the response, three rhesus monkeys were trained on a behavioral task in which ...
Glutamate transmission and toxicity in alzheimer's disease
(Elsevier, 1988)
1. 1. Despite intensive research, the cause of Alzheimer's disease is unknown.2. 2. Glutamate is the major excitatory transmitter of the cerebral cortex and hippocampus and it appears to have an important role in learning ...
Fever and leukocytosis: Physical manifestations of bipolar affective disorder?
(Elsevier, 1988)
1. 1. Fever and leukocytosis are occasionally observed in patients with psychiatric disorders. A thorough medical evaluation does not always reveal the origin of these abnormalities.2. 2. We report the case histories of ...
Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy
(Elsevier, 1983)
1. 1. Specific binding of 3H-clonidine to alpha2 adrenoreceptors upon human blood platelet membranes is increased in patients with major depressive disorder (endogenous depression).2. 2. Specific binding of 3H-yohimbine ...
Y-Maze behavior after an analog of ACTH 4-9, evidence for an attentional alteration
(Springer-Verlag, 1980-11)
Adult, male, Swiss-Webster mice were injected with either control solution or various doses of a long-acting analog of ACTH 4-9. The drug produced significant alterations in performance in an equiangular Y-maze. In comparison ...
Selective blockade of the discriminative stimulus effects of pentobarbital in pigeons
(Springer-Verlag, 1981-11)
The ability of CNS stimulants to block the discriminative effects of pentobarbital was studied in pigeons trained to discriminate IM pentobarbital (5 mg/kg) from saline. Pentobarbital, when administered alone, consistently ...
Anticonvulsant drug actions on GABA responses and sustained repetitive firing of neurons in cell culture
(Elsevier, 1984-07)
We have studied barbiturate, benzodiazepine (BDZ), [beta]-carboline, triazolopyridazine, piperazine carboxylate, hydantoin, iminostilbene, valproate, and succinmide actions on GABA responses and sustained, high frequency ...
Behavior maintained by intravenous injection of codeine, cocaine, and etorphine in the rhesus macaque and the pigtail macaque
(Springer-Verlag, 1980-10)
Lever-pressing behavior of two species of macaque, the rhesus macaque ( M. mulatta ) and the pigtail macaque ( M. nemestrina ) was maintained by intravenous injection of codeine, etorphine, or cocaine. Monkeys responded ...
Effects of an ACTH 4-9 related peptide upon intracranial self stimulation and general activity in the rat
(Springer-Verlag, 1980-11)
Adult male Sprague-Dawley rats were stereotactically implanted with electrodes within the anterior medial forebrain bundle: The rats were trained to respond for intracranial self-stimulation (ICS) and treated with control ...