Now showing items 31-40 of 62
Potentiation of L-DOPA induced motor activity by an inhibitor of phenylethanolamine-N-methyltransferase
(Elsevier, 1980)
1. 1. Pharmacological inhibition of phenylethanolamine-N-methyltransferase (PNMT), the synthesizing enzyme for adrenaline, resulted in enhanced behavioral activation by 3,4,-dihydroxyphenylalanine (L-DOPA) in mice.2. 2. ...
Mecamylamine pretreatment increases subsequent nicotine self-administration as indicated by changes in plasma nicotine level
(Springer-Verlag, 1987-09)
Acute administration of mecamylamine, a centrally active nicotinic cholinergic agonist, has been shown to increase amount of smoking as indicated by smoking topography (e.g., puff rate, puff duration), expired carbon ...
Cholinergic properties of desipramine and amoxapine: Assessment using a thermoregulation paradigm
(Elsevier, 1987)
1. 1. The withdrawal of tricyclic antidepressants (TCAs) produces symptoms suggesting cholinergic rebound.2. 2. Amitriptyline (AMI), the most potent antimuscarinic agent among this class of drugs, produces supersensitivity ...
Similarity of the discriminative stimulus effects of ketamine, cyclazocine, and dextrorphan in the pigeon
(Springer-Verlag, 1981-05)
Separate groups of pigeons were trained to discriminate the IM injection of ketamine, cyclazocine, or dextrorphan from saline. Each of the training drugs and phencyclidine produced dose-related, drug-appropriate responding ...
Comparison of acute and chronic lithium treatment on 3 H-norepinephrine uptake by rat brain slices
(Springer-Verlag, 1980-01)
The effects of lithium chloride, given IP in high (2.5–15 mEq/kg) and low (1.25 mEq/kg) doses twice daily, upon 3 H-norepinephrine uptake and retention were examined with slices from four regions of the rat brain, namely ...
The effects of antidepressants on the retention and metabolism of [3H]-norepinephrine in rat brain slices
(Elsevier, 1981-04)
Tricylic antidepressants acutely decrease the neuronal retention of [3H]-norepinehrine ([3H]-NE) by blocking neuronal membrane uptake and/or vesicular uptake and binding. To distinguish between effects upon the plasma ...
Interaction of synthetic opioid metenkephalin peptide analogs, lilly 127623 and FK 33-824 with indole hallucinogens: Antagonism of N,N-dimethyltryptamine- and LSD-induced disruption of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1983-07)
The selected opioid metenkephalin synthetic peptide analogs Lilly (LY) 127623 and FK 33-824 were tested for behavioral dose effects and potential interaction with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 ...
Role of serotonergic mechanisms in animal models of predation
(Elsevier, 1980)
1. 1. A short critical review of the role of serotonin in predatory attack is given.2. 2. Among factors determining the degree and type of psychopharmacological involvement are: species, drug, and dependent behavioral ...
Effects of selected opioid agonists and antagonists on DMT-and LSD-25-induced disruption of food-rewarded bar pressing behavior in the rat
(Springer-Verlag, 1981-11)
Several opioid agonists and antagonists interact with N,N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) in adult male Holtzman rats trained on a positive reinforcement, fixed ratio 4 (FR 4 ) behavioral ...
Coupling of multiple opioid receptors to GTPase following selective receptor alkylation in brain membranes
(Elsevier, 1987-12)
Opioid agonists of the mu, kappa and delta types stimulated low-Km guanosine triphosphatase (GTPase) in membranes, from the brain of the rat by up to 34%, with potencies the rank order of which corresponded to the respective ...