Now showing items 71-80 of 261
Role of alcohol P-450-oxygenase (APO) in microsomal ethanol oxidation
(Elsevier, 1985)
The form of liver microsomal cytochrome P-450 induced by chronic administration of ethanol to rabbits, designated as P-450 or P-450 isozyme 3a, has been purified to homogeneity as judged by several criteria, including NH2- ...
Identification of gastrin molecular variants in gastrinoma syndrome
(Elsevier, 1987-02)
The molecular species of gastrin in the circulation and in tumor extracts were studied in two groups of patients: (1) with benign gastrinoma and (2) with gastrinoma with liver metastases. Radioimmunoassays (RIAs) and ...
One-step purification of murine IgM and human [alpha]2-macroglobulin by affinity chromatography on immobilized snowdrop bulb lectin
(Elsevier, 1988-12)
A new mannose-specific plant lectin (GNA) isolated from the snowdrop bulb was immobilized on Sepharose 4B and employed for the purification of certain glycoproteins with high-mannose type glycan chains. Murine IgM bound ...
Determination of plasma trimetrexate levels using gas chromatography--mass spectrometry with selected-ion monitoring
(Elsevier, 1986)
Trimetrexate is a potent inhibitor of dihydrofolate reductase and has demonstrated significant antitumor activity against murine and human cell lines both in vitro and against several murine transplanted tumors. The ...
Analysis of polybrominated biphenyls by gas chromatography with electron-capture detection
(Elsevier, 1982-02-05)
The structure-sensitivity relationship of polybrominated biphenyls analyzed by an electron-capture detector was investigated. The greates variations i n sensitivity with positional isomerism occurred for the least brominated ...
Changes occur in central adrenoreceptor function following long-term morphine treatment and during morphine withdrawal
(Elsevier, 1984-12)
Radioloigand binding techniques were used in combination with electrophysiological recording to characterize changes in beta adrenoreceptor activity in various brain areas in rats treated chronically with morphine. Following ...
Photodiode array ultraviolet spectrophotometric profiling of carboxylic acids in physiological fluids
(Elsevier, 1985)
In this paper the use of a computer-controlled photodiode array spectrophotometric detector for the high-performance liquid chromatographic (HPLC) profiling of carboxylic acids in physiological fluids is reported. The ...
A comparison of cholesteryl oleate and 19-iodocholesteryl oleate as substrates for adrenal cholesterol esterase
(Elsevier, 1980-04)
Radiolabeled 19-iodocholesterol is widely used to obtain images of human adrenals. We have shown in rats and mice that 85-95% of the radiolabel is present in the esterified form. Using rat adrenal cytosolic cholesterol ...
Comparison of "selective" opiate receptor antagonists on the isolated mouse vas deferens
(Elsevier, 1984-12)
The selectivity and relative potencics of opiate receptor antagonists were compared on the mouse vas deferens preparation. ICI-174864 was found to be a highly selective antagonist at delta opiate receptors equal in potency ...
Solid phase enzyme-linked competitive binding assay for riboflavin
(Elsevier, 1988-01)
A new solid-phase enzyme-linked assay for riboflavin (vitamin B2) is described. The assay is based on the competition between analyte vitamin molecules and a glucose-6-phosphate dehydrogenase-3-carboxymethylriboflavin ...