Now showing items 431-440 of 463
A synthesis of (+)-7-Epiaustraline and (-)-7-Epialexine
(Elsevier, 1991-09-30)
Reductive cyclization of the azido epoxides 19[alpha] and 19[beta] followed by deprotection afforded the HIV inhibitor (+)-7-epiaustraline 7 and (-)-7-epialexine 9. The formation of 7 proceeded with an unusual inversion ...
Synthesis of a disulfide cross-linked DNA triple helix
(Elsevier, 1994-06-27)
An intramolecular DNA triple helix incorporating a disulfide cross-link has been synthesized. Potassium permanganate footprinting and UV melting analysis demonstrate that the cross-link increases the conformational stability ...
α- d -Galactosylation of surface fucoglycoconjugate(s) upon stimulation/activation of murine peritoneal macrophages
(Kluwer Academic Publishers; Chapman & Hall ; Springer Science+Business Media, 1992-04)
Murine resident macrophages express, on their surface, carbohydrate epitopes which undergo changes during their stimulation/activation as monitored by binding of 125 I labelled Evonymus europaea and Griffonia simplicifolia ...
Distribution of GABA A and GABA B receptors in mammalian brain: Potential targets for drug development
(Wiley Subscription Services, Inc., A Wiley Company, 1990)
GABA is the major inhibitory neurotransmitter in mammalian brain. GABA receptors and the metabolism of GABA are significant targets for new centrally acting drugs to treat neurological and behavioral disorders. The simple ...
Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats
(Springer-Verlag, 1991-04)
This experiment was designed to characterize the withdrawal syndrome produced by discontinuation of treatment with escalating, non-neurotoxic doses of d -amphetamine (AMPH). AMPH withdrawal was associated with both transient ...
ACE Inhibitors in Heart Failure: Prospects and Limitations
(Kluwer Academic Publishers; Springer Science+Business Media, 1997-05)
ACE inhibitors have been shown to be effective in reducing the morbidity and mortality of patients with left ventricular systolic dysfunction, but their application to clinical practice in this situation is still limited. ...
Fermi-liquid-type spectral function and angle resolved photoelectron spectra of the Ti-3dz2-band of TiTe2
(Elsevier, 1994-05-06)
Angle and temperature dependent photoelectron spectra with high energy and momentum resolution ([Delta]E = 300meV, [Delta][theta]Eb eV) of the quasi-two-dimensional, metallic layer compound TiTe2 along the direction . The ...
Antibody-antigen complex formation with immobilized immunoglobulins
(Elsevier, 1992-08-15)
We have investigated the complex formation between an immobilized monoclonal antibody and antigens that differ in size about 50-fold. As a model system, we used an iodinated progesterone derivative and a progesterone-horseradish ...
Preparation of polyfunctional diorganomercurials and their transmetallation to diorganozincs. Applications to the preparation of optically active secon
(Elsevier, 1992-10-13)
Two new methods of preparation of functionalized diorganomercurials have been developed. The first method involves a substitution reaction of (ICH2 Their transmetallation with zinc dust (toluene, 80[deg]C, 3-5 h) affords ...
Carbohydrate-binding specificity of the daffodil (Narcissus pseudonarcissus) and amaryllis (Hippeastrum hybr.) bulb lectins
(Elsevier, 1990-06)
The carbohydrate binding specificity of the daffodil (Narcissus pseudonarcissus; NPA) and amaryllis (Hippeastrum hybr.; HHA) lectins, isolated from extracts of their bulbs by affinity chromatography on immobilized mannose, ...