Now showing items 1-10 of 463
High levels of non-activated receptors in glucocorticoid-sensitive S49wt mouse lymphoma cells incubated with dexamethasone
(Elsevier, 1994-10)
Upon agonist binding the heteromeric glucocorticoid receptor complex under goes a conformational change (receptor activation). This event involves the dissociation of a dimer of 90 kDa heat shock proteins. Whereas receptor ...
Interaction of linear manno-oligosaccharides with three mannose-specific bulb lectins. Comparison with mannose/glucose-binding lectins
(Elsevier, 1992-05-22)
Three new mannose-binding lectins, isolated from daffodil (NPA), amaryllis (HHA), and snowdrop (GNA) bulbs, are capable of precipitating with a linear mannopentaose (Man[alpha]1-3Man[alpha]1-3Man[alpha]1-3Man[alpha]1-2Man). ...
Characterization of gastrin amidation in the rat and porcine antrum: comparison with the pituitary
(Elsevier, 1990-04-24)
The formation of biologically active gastrin from glycine-extended processing intermediates occurs via the action of a peptide [alpha]-amidating enzyme. The observation that gastrin exists primarily as unamidated precursors ...
Fusion of mercury a new certified standard for differential scanning calorimetry
(Elsevier, 1990-03)
From the results of adiabatic-calorimetric measurements, mercury has been certified as a standard reference material for temperature and enthalpy of fusion for differential scanning calorimetry. The fusion temperature is ...
Evaluation of amonafide in disseminated malignant melanoma
(Kluwer Academic Publishers; Springer Science+Business Media, 1993-06)
Amonafide (AMF), NSC 308847 is an investigational anticancer drug acting as a DNA intercalating agent. This paper presents results of a phase II clinical study of AMF in disseminated malignant melanoma. Twenty patients, ...
Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-01)
Ketamine is an N -methyl- D -aspartate (NMDA) receptor antagonist with psychotogenic and dissociative effects in healthy humans. These cognitive and perceptual effects in humans are reportedly reduced by benzodiazepine ...
On-line multichannel Raman spectroscopic detection system for capillary zone electrophoresis
(Elsevier, 1991)
An on-line multichannel Raman spectroscopic detection system for capillary zone electrophoresis using a charge-coupled device as the detector is described. Resonant, near-resonant and non-resonant excitation Raman ...
CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor
(Elsevier, 1994)
The ability of CCKA antagonists to inhibit full and partial CCK agonists of the rat pancreatic acinar cell CCKA receptor has been studied. When isolated rat pancreatic acini were superfused with CCK-8 (10 pM-1 nM) or CCK-4 ...
Interaction of five -mannose-specific lectins with a series of synthetic branched trisaccharides
(Elsevier, 1991-06-25)
The interaction of a series of synthetic, branched trisaccharides with five -mannose-specific lectins was studied by precipitation-inhibition assay. The branched methyl [alpha]--mannotrioside, [alpha]--Manp-(1-->3)-[[ ...