Now showing items 41-50 of 465
Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-09)
Purpose : We have reported previously that the expression of E. coli dUTPase (dutE) can protect HT29 cells from 5-fluorodeoxyuridine (FdUrd)-induced DNA fragmentation and cytotoxicity. In the study reported here, we further ...
Biological effects of a novel intestinal peptide -- inhibiting enterocytogenin on cultured 3T3 mouse fibroblasts and L5178Y mouse lymphoma cells
(Elsevier, 1994-05-05)
The effects of a new intestinal peptide, inhibiting enterocytogenin (IEG) derived from pig intestinal mucosa were studied in vitro on 3T3 mouse fibroblasts and L5178Y mouse lymphoma cell line. IEG caused considerable growth ...
An intramolecular, Schmidt reaction of an alkyl azide with a carbocation. The generation and rearrangement of a conformationally restricted secondary aminodiazonium ion.
(Elsevier, 1992-09-08)
Treatment of azidoalkene 2 with triflic acid produced the bridged bicyclic enamine 3 by an intramolecular Schmidt reaction. Rearrangement of the intermediate aminodiazonium ion 5 is completely regioselective.
Studies on morpholinosphingolipids: Potent inhibitors of glucosylceramide synthase
(Elsevier, 1994-04-25)
Synthetic 1-morpholino-1-deoxyceramides were designed to inhibit glucosylceramide synthase. The most potent inhibitor 2a possesses the unnatural R,R-configuration of D-threo-sphingosine.
Transferrin: A potential source of iron for oxygen free radical-mediated endothelial cell injury
(Elsevier, 1992-04)
The ability of transferrin to potentiate oxygen free radical-mediated endothelial cell injury was assessed. 51Cr-labeled endothelial cells derived from rat pulmonary arteries (RPAECs) were incubated with hydrogen peroxide ...
Expression of prodynorphin-derived peptides and mRNA in guinea-pig cortex
(Elsevier, 1993-08)
The distributions and extent of processing of four prodynorphin-derived peptides (dynorphin A (1-17), dynorphin A (1-8), dynorphin B, and [alpha]-neoendorphin) were determined in ten regions of the cortex as well as in the ...
Studies on human serum paraoxonase/arylesterase
(Elsevier, 1993-06)
The complete amino acid sequence of human serum paraoxonase/arylesterase and the DNA sequence coding for that protein have recently been determined in two independent laboratories. There is now considerable evidence that ...
S1.23 Investigation of the sialyltransferases present in two populations of ehrlich ascites tumor cells
(Kluwer Academic Publishers; Chapman & Hall ; Springer Science+Business Media, 1993-08)
Inactivation of Escherichia coli 2-amino-3-ketobutyrate CoA ligase by phenylglyoxal and identification of an active-site arginine peptide
(Elsevier, 1992-11-15)
Treatment of homogeneous preparations of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli, a pyridoxal 5'-phosphate-dependent enzyme, with phenylglyoxal, 4-(oxyacetyl)phenoxyacetic acid, 2,3-butanedione, or ...