Now showing items 11-20 of 44
Discriminative and reinforcing effects of brotizolam in rhesus monkeys
(Springer-Verlag, 1991-02)
The reinforcing and discriminative stimulus effects of brotizolam, a benzodiazepine-hypnotic, were evaluated in rhesus monkeys. In one experiment, separate groups of monkeys ( N =3/group) were trained to discriminate ...
Quadazocine decreases responding reinforced by ethanol, sucrose, and phencyclidine fluid deliveries in rhesus monkeys: comparison to naltrexone’s effects
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1999-06)
Rationale: The endogenous opioid system may mediate the reinforcing effects of ethanol as well as sweet-tasting solutions. For example, opioid antagonists, such as naltrexone, reduce ethanol- and sucrose-reinforced ...
Chronic treatment with ethanol produces supersensitivity to oxotremorine
(Elsevier, 1990)
1. The effect of chronic treatment with ethanol (14% v:v in drinking water) on the physiological endpoint core temperature which is partially regulated by a muscarinic mechanism was measured in adult male rats (n = 8).2. ...
Aggression, anxiety and vocalizations in animals: GABA A and 5-HT anxiolytics
(Springer-Verlag, 1995-09)
A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. ...
Current benzodiazepine issues
(Springer-Verlag, 1995-03)
This article deals with some of the recent evidence bearing on the issues of the liability of benzodiazepines to lead to abuse, dependence, and adverse behavioral effects. Reviews of epidemiological, clinical and experimental ...
Discriminative stimulus effects of a centrally administered, delta-opioid peptide (d-Pen2-d-Pen5-enkephalin) in pigeons
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1996-10)
The present study assessed the discriminative stimulus effects of the delta-opioid agonist [ d -Pen 2 - d -Pen 5 ]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between ICV injections ...
Telemetric measurement of core temperature in pharmacological research: Validity and reliability
(Elsevier, 1990)
1. The authors present data establishing the reliability and validity of a method for telemetrically measuring core temperature.2. The method is designed to be of particular utility to psychobiological researchers.
Euphoriant effects of nicotine in smokers
(Springer-Verlag, 1992-09)
Two studies were conducted to replicate and extend previous demonstrations of smoking-induced, dose-related reports of euphoria, and to confirm this relationship using measures of plasma nicotine. In experiment 1, ...
The development of sensitization to the psychomotor stimulant effects of amphetamine is enhanced in a novel environment
(Springer-Verlag, 1995-02)
Two experiments were designed to assess the effect of a “novel” environment on the development of sensitization to the psychomotor activating effects of d -amphetamine. In the first experiment, rats with a unilateral ...