Now showing items 21-30 of 161
Use of an Inhibitor of Glucosylceramide Synthesis, D-1-Phenyl-2-decanoylamino-3-morpholino-1 -propanol
(Elsevier, 1993-10)
Methods for the synthesis, purification, and use of an inhibitor of glucosylceramide synthesis (PDMP or D-1-phenyl-2-decanoylamino-3-morpholino-1-propanol) are given. The inhibitor is effective with a variety of cells and ...
Distinguishing between depression and dementia in the elderly: A review of neuropsychological findings
(Elsevier, 1993)
Distinguishing between cognitive deficits seen in depression and progressive dementing, diseases is complex and often difficult clinically. We review recent neuropsychological studies comparing normal elderly individuals, ...
CSF somatostatin in Alzheimer's disease and major depression: Relationship to hypothalamic-pituitary-adrenal axis and clinical measures
(Elsevier, 1993)
Patients with Alzheimer's disease (AD) and major depression have been shown to have overlapping clinical symptoms and biological markers, including decreased concentrations of cerebrospinal fluid (CSF) somatostatin-like ...
Changes at multiple levels of the hypothalamo-pituitary adrenal axis following repeated electrically induced seizures
(Elsevier, 1990)
Seizures, including electrically induced seizures (ECS), activate the hypothalamo-pituitary-adrenal (HPA) axis in rats. The present studies were undertaken to characterize the effects of repeated ECS on hormone release and ...
Axonal outgrowth within the abnormal scaffold of brain tracts in a zebrafish mutant
(Wiley Subscription Services, Inc., A Wiley Company, 1994-04)
The role of specific axonal tracts for the guidance of growth cones was investigated by examining axonal outgrowth within the abnormal brain tracts of zebrafish cyclops mutants. Normally, the earliest differentiating ...
Local regeneration in the retina of the goldfish
(Wiley Subscription Services, Inc., A Wiley Company, 1992-03)
We have studied regeneration of the retina in the goldfish as a model of regenerative neurogenesis in the central nervous system. Using a transsclearal surgical approach, we excised small patches of retina that were replaced ...
Changes in medial cortical blood flow with a stimulus-response compatibility task
(Elsevier, 1994-02)
Previous work has suggested that human subjects engaged in tasks, like the Stroop task, that require response selection utilize the medical frontal cortex. We used positron emission tomography to measure blood flow changes ...
Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS
(Elsevier, 1990-12-11)
Five-channel silicon-based microprobes were sputter-coated with carbon, coated with Nafion, and used for both in vivo electrochemical and single-unit electrophysiological recordings. High-speed electrochemical studies were ...
Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines
(Elsevier, 1992-10)
Insulin-like growth factors (IGF) I and II are polypeptides with both growth-promoting and insulin-like metabolic effects. The developmentally specific expression of IGF I and II in the nervous system implies a role for ...
Acquisition of regional and cellular identities in the developing zebrafish nervous system
(Elsevier, 1992-02)
In the past year, several new techniques have been used with great success in the study of nervous system development in the zebrafish. Perhaps the most exciting results have come from experiments in which single identified ...