Now showing items 1-10 of 145
High levels of non-activated receptors in glucocorticoid-sensitive S49wt mouse lymphoma cells incubated with dexamethasone
(Elsevier, 1994-10)
Upon agonist binding the heteromeric glucocorticoid receptor complex under goes a conformational change (receptor activation). This event involves the dissociation of a dimer of 90 kDa heat shock proteins. Whereas receptor ...
Characterization of gastrin amidation in the rat and porcine antrum: comparison with the pituitary
(Elsevier, 1990-04-24)
The formation of biologically active gastrin from glycine-extended processing intermediates occurs via the action of a peptide [alpha]-amidating enzyme. The observation that gastrin exists primarily as unamidated precursors ...
On-line multichannel Raman spectroscopic detection system for capillary zone electrophoresis
(Elsevier, 1991)
An on-line multichannel Raman spectroscopic detection system for capillary zone electrophoresis using a charge-coupled device as the detector is described. Resonant, near-resonant and non-resonant excitation Raman ...
CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor
(Elsevier, 1994)
The ability of CCKA antagonists to inhibit full and partial CCK agonists of the rat pancreatic acinar cell CCKA receptor has been studied. When isolated rat pancreatic acini were superfused with CCK-8 (10 pM-1 nM) or CCK-4 ...
cDNA and derived amino acid sequence of rabbit nasal cytochrome P450NMb (P450IIG1), a unique isozyme possibly involved in olfaction
(Elsevier, 1991-02-15)
Olfactory-specific cytochrome P450NMb was previously purified to electrophoretic homogeneity from microsomes of rabbit nasal mucosa in this laboratory. In the present study, a cDNA library made from poly(A)+ RNA from rabbit ...
Actin polymerization in cellular oxidant injury
(Elsevier, 1991-08-01)
Microfilaments undergo an ATP-dependent disruption into shortened bundles following cellular exposure to oxidants. This phenomenon does not require a net change in the amount of polymerized actin. However, increased amounts ...
Hormonal regulation of steroidogenic enzyme gene expression in Leydig cells
(Elsevier, 1992-12)
In normal mouse Leydig cells, steady state levels of mRNA of CYP11A, 3[beta]-hydroxysteroid dehydrogenase [Delta]5- > [Delta]4-isomerase (3[beta]HSD), and CYP17 are differentially regulated. There is high basal expression ...
Immunohistochemical localization of the mu opioid receptors
(Elsevier, 1994-11-10)
Using antibodies generated to the C-terminal 63 amino acids of the cloned rat mu receptor, the present study examines the distribution of the mu receptor-like immunoreactivity (li) in perfused rat brain sections. Generally, ...