Now showing items 1-10 of 34
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
(Springer-Verlag, 2005-11)
Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression ...
Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats
(Springer-Verlag, 2002-10)
Abstract
Modulation of morphine sensitization in the rat by contextual stimuli
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-08)
Rationale: The repeated administration of addictive drugs, such as amphetamine, cocaine, and morphine, produces a progressive enhancement (sensitization) of their psychomotor activating effects. We have previously shown ...
Assessing methylphenidate preference in ADHD patients using a choice procedure
(Springer-Verlag, 2004-10)
Methylphenidate (MPH) is widely used in the treatment of attention deficit hyperactivity disorder (ADHD) and is associated with positive clinical effects across a wide range of domains. Despite the clinical effectiveness ...
Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse
(Springer-Verlag, 2005-09)
Drug challenges in “intact” and p -chlorophenylalanine ( p -CPA)-treated animals can be used to distinguish agents that act as direct serotonin (5-HT) agonists from agents that function as 5-HT releasers.
Self-administration of fentanyl, cocaine and ketamine: effects on the pituitary–adrenal axis in rhesus monkeys
(Springer-Verlag, 2004-11)
Drugs of abuse can affect the functioning of the hypothalamic–pituitary–adrenal (HPA) axis. Acute administration of drugs that serve as reinforcers have been observed to stimulate the rat HPA axis, leading to the suggestion ...
Self-administration of methohexital, midazolam and ethanol: effects on the pituitary–adrenal axis in rhesus monkeys
(Springer-Verlag, 2005-02)
There is disagreement in the literature with respect to how drugs of abuse affect the functioning of the hypothalamic–pituitary–adrenal (HPA) axis, and whether these changes in endocrine function may be related to the ...
Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers
(Springer-Verlag, 2006-04)
Preclinical investigations have established that methamphetamine (MA) produces long-term changes in dopamine (DA) neurons in the striatum. Human studies have suggested similar effects and correlated motor and cognitive ...