Now showing items 21-30 of 34
Methoclocinnamox: time course of changes in alfentanil-reinforced responding in rhesus monkeys
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-03)
Rationale : Methoclocinnamox (MC-CAM) possesses initial partial µ-opioid agonist activity with subsequent long-lasting µ-antagonist effects. This profile of activity is similar to that of buprenorphine, a compound with ...
Desipramine attenuates working memory impairments induced by partial loss of catecholamines in the rat medial prefrontal cortex
(Springer-Verlag, 2006-01)
The density of tyrosine hydroxylase-immunoreactive (TH-IR) axons in the prefrontal cortex of schizophrenic subjects may be reduced by as much as 50% in the deep cortical layers (Am J Psychiatry 156:1580–1589, 1999). ...
Determinants of the behavioral effects of opioids and their antagonists: contributions of the Laboratory of Psychobiology
(Springer-Verlag, 2002-10)
Abstract
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
(Springer-Verlag, 2001-12)
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects drug-taking behavior to the same extent across all individual animals, ...
Environmental modulation of the response to amphetamine: dissociation between changes in behavior and changes in dopamine and glutamate overflow in the rat striatal complex
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-08)
Rationale: We have previously shown that environmental novelty enhances the behavioral activating effects of amphetamine and amphetamine-induced expression of the immediate early gene c- fos in the striatal complex, ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
Effects of contextual or olfactory cues previously paired with morphine withdrawal on behavior and pain sensitivity in the rat
(Springer-Verlag, 2001-08)
Rationale: Pavlovian conditioning processes have been accorded an important role in maintaining persistent opiate administration. At least one locus for this contribution is during opiate withdrawal. These experiments ...
Differential development of behavioral tolerance and the subsequent hedonic effects of alcohol in AA and ANA rats
(Springer-Verlag, 2000-09)
Rationale: There at least two ways in which tolerance development to alcohol's behavioral effects could interact with its subsequent intake: 1) tolerance to alcohol's reward or reinforcing effects per se could lead to ...
Expression of behavioral sensitization to ethanol by DBA/2J mice: the role of NMDA and non-NMDA glutamate receptors
(Springer-Verlag, 2003-05)
Rationale. Behavioral sensitization has been accorded a central role in contemporary theories of drug addiction. Accordingly, a substantial effort has been made to determine the processes mediating sensitization to ...
Chronic administration of the delta opioid receptor agonist (+)BW373U86 and antidepressants on behavior in the forced swim test and BDNF mRNA expression in rats
(Springer-Verlag, 2005-11)
Selective delta opioid receptor agonists have been shown to produce antidepressant-like behavioral effects and increase brain-derived neurotrophic factor (BDNF) mRNA expression when given acutely, but the chronic effects ...