Now showing items 21-30 of 541
Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization
(Wiley Subscription Services, Inc., A Wiley Company, 2004-09-01)
Current treatment protocol for postoperative pain is to infuse anesthetic solution around nerves or into the epidural space. This clinical practice is beset by the short duration of the anesthetic effect unless the infusion ...
Oligoribonucleotides with 2′‐O‐(tert‐Butyldimethylsilyl) Groups
(Wiley Periodicals, Inc.IRL Press,, 2000-07)
The chemical synthesis of oligoribonucleotides on solid support is routinely performed via the phosphoramidite method. However, the additional 2‐OH function of the ribofuranosyl sugar requires suitable protection during ...
Determination of Binding Mode: Intercalation
(Academic PressWiley Periodicals, Inc., 2000-02)
A small molecule can be assumed to bind to DNA by intercalation between base pairs if it causes lengthening and unwinding of the DNA helix and undergoes changes in its spectral properties, such as DNA‐induced hypochromism ...
Early events of Bacillus anthracis germination identified by time-course quantitative proteomics
(WILEY-VCH Verlag, 2006-10)
Germination of Bacillus anthracis spores involves rehydration of the spore interior and rapid degradation of several of the protective layers, including the spore coat. Here, we examine the temporal changes that occur ...
Cellular Delivery of Locked Nucleic Acids (LNAs)
(Wiley Periodicals, Inc., 2002-06)
Locked nucleic acids (LNAs) are RNA derivatives that have an O‐methylene linkage between the 2 and 4 positions of the ribose. This leads to exceptionally high‐affinity binding to complementary sequences. They are synthesized ...
Use of inverse PCR to amplify and sequence breakpoints of HPRT deletion and translocation mutations
(John Wiley & Sons, Inc., 2002)
Deletion and translocation mutations have been shown to play a significant role in the genesis of many cancers. The hprt gene located at Xq26 is a frequently used marker gene in human mutational studies. In an attempt ...
The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2001-01)
The recently described CC chemokine, 6C-kine, is unique in that it contains -six rather than the usual four conserved cysteines typical of this family. Furthermore, murine 6C-kine binds to one of the CXC chemokine receptors ...
Prevention of visual stress and migraine with precision spectral filters
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Individuals who suffer migraine, particularly migraine with visual aura (MwA), are susceptible to physiologically strong visual stimuli and find them aversive. Strong stimuli including bright light and certain visual ...
Low-Temperature SCR of NO with NH 3 over USY-Supported Manganese Oxide-Based Catalysts
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2003-04)
A series of catalysts of manganese oxide, manganese–cerium and iron–manganese oxide supported on USY (ultra-stable Y zeolite) were studied for the low-temperature selective catalytic reduction (SCR) of NO with ammonia in ...