Now showing items 51-60 of 541
Mycobacterium avium Subspecies Paratuberculosis in the Inflamed Gut Tissues of Patients with Crohn’s Disease in China and its Potential Relationship to the Consumption of Cow’s Milk: A Preliminary Study
(Kluwer Academic Publishers; Springer, 2005-10)
Mycobacterium avium subspecies paratuberculosis infection in domestic livestock is widespread in many countries throughout the world. Studies in Europe and the USA show that M. avium subspecies paratuberculosis can be ...
Different obscurin isoforms localize to distinct sites at sarcomeres
(Wiley Periodicals, Inc., 2007-04-17)
Protection of 2′‐Hydroxy Functions of Ribonucleosides
(Oxford University PressWiley Periodicals, Inc., 2000-02)
The main purpose of this article is to discuss 2′‐protection in the context of effective oligoribonucleotide synthesis. Emphasis is placed on the 2′‐protecting groups of choice in the synthesis of oligo‐and polyribonucleotides, ...
Predicting structurally conserved contacts for homologous proteins using sequence conservation filters
(Wiley Subscription Services, Inc., A Wiley Company, 2009-11-01)
The prediction of intramolecular contacts has a useful application in predicting the three-dimensional structures of proteins. The accuracy of the template-based contact prediction methods depends on the quality of the ...
Improving estimates of genetic maps: a meta-analysis-based approach
(Wiley Subscription Services, Inc., A Wiley Company, 2007-07)
Inaccurate genetic ( or linkage ) maps can reduce the power to detect linkage, increase type I error, and distort haplotype and relationship inference. To improve the accuracy of existing maps, I propose a meta-analysis-based ...
Synthesis and Purification of Oligonucleotide N3′→︀P5′ Phosphoramidates and their Phosphodiester and Phosphorothioate Chimeras
(Wiley Periodicals, Inc., 2000-12)
This unit describes the synthesis and purification of oligonucleotide N3′→︀P5′ phosphoramidates, wherein each 3′‐oxygen is replaced by a 3′‐amine in the 2′‐deoxyribose ring. The synthesis of required monomers and application ...
Development of adenovirus immobilization strategies for in situ gene therapy
(John Wiley & Sons, Ltd., 2008-10)
Background Regenerative gene therapy using viral vectors enables transduced cells to express bioactive factors in vivo . Viral delivery with spatial control can enhance transduction efficiency and may limit systemic ...
Iterative cluster-NMA: A tool for generating conformational transitions in proteins
(Wiley Subscription Services, Inc., A Wiley Company, 2009-02-15)
Computational models provide insight into the structure–function relationship in proteins. These approaches, especially those based on normal mode analysis, can identify the accessible motion space around a given equilibrium ...