Now showing items 21-30 of 564
In vivo measures of dopaminergic radioligands in the rat brain: Equilibrium infusion studies
(John Wiley & Sons, Inc., 2002-03-01)
The application of an equilibrium infusion method for measuring specific in vivo radioligand binding in the conscious rat brain was evaluated for two ligands of the dopaminergic system, (+)-Α-[ 11 C]dihydrotetrabenazine ...
Rates of evolution on the time scale of the evolutionary process
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-11)
A generational time scale, involving change from one generation to the next, is the time scale of evolution by natural selection. Microevolutionary and macroevolutionary patterns reflect this process on longer time scales. ...
The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy
(John Wiley & Sons, Ltd, 2008-09)
Interrelations of myogenic response, progressive atrophy of muscle fibers, and cell death in denervated skeletal muscle
(John Wiley & Sons, Inc., 2001-10-01)
Little is known concerning the time-course and structural dynamics of reactivation of compensatory myogenesis in denervated muscle, its initiating cellular mechanisms, and the relationship between this process and the ...
Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element
(Wiley Subscription Services, Inc., A Wiley Company, 2009-08-15)
A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 ...
Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex
(Wiley Subscription Services, Inc., A Wiley Company, 2006-09-15)
Alterations of molecules that mediate dopaminergic signal transduction have been found in schizophrenia, supporting the hypothesis of altered dopaminergic neurotransmission in this illness. To further explore this hypothesis, ...
Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 mice
(Wiley Subscription Services, Inc., A Wiley Company, 2008-06)
Huntington's disease (HD) is a neurodegenerative disorder caused by an elongation of CAG repeats in the HD gene, which encodes a mutant copy of huntingtin with an expanded polyglutatmine repeat. Individuals who are ...
The effect of mean and variance in resource supply on survival of annuals from Mediterranean and desert environments
(Springer-Verlag, 2004-10)
Resource availability is often characterized by mean annual amounts, while ignoring the spatial variation within habitats and the temporal variation within a year. Yet, temporal and spatial variation may be especially ...
Receptor-related interactions of opiates with PGE-induced adneylate cyclase in brain
(Elsevier, 2006-04-07)
The inhibition by opiates of the PGE2-induced formation of cAMP in slices from rat brain striatum was investigated. A maximal, 3.5-fold increase over the basal level of cAMP was obtained with an EC50 for PGE2 of 3 [mu]M. ...
Understanding the accuracy of statistical haplotype inference with sequence data of known phase
(Wiley Subscription Services, Inc., A Wiley Company, 2007-11)
Statistical methods for haplotype inference from multi-site genotypes of unrelated individuals have important application in association studies and population genetics. Understanding the factors that affect the accuracy ...