Now showing items 11-18 of 18
Classifications of ovarian cancer tissues by proteomic patterns
(WILEY-VCH Verlag, 2006-11)
Ovarian cancer is a morphologically and biologically heterogeneous disease. The identification of type-specific protein markers for ovarian cancer would provide the basis for more tailored treatments, as well as clues for ...
Improved Electrochemical Analysis of Neuropathy Target Esterase Activity by a Tyrosinase Carbon Paste Electrode Modified by 1-Methoxyphenazine Methosulfate
(Kluwer Academic Publishers; Springer, 2005-08)
A graphite-paste tyrosinase biosensor was improved by adding 1-methoxyphenazine methosulfate as a mediator. Mediator modification enhanced sensitivity to phenol 4-fold and long-term stability 3-fold. Phenol could be detected ...
The interaction profile of homologous recombination repair proteins RAD51C, RAD51D and XRCC2 as determined by proteomic analysis
(WILEY-VCH Verlag, 2009-08)
The RAD51 family of proteins is involved in homologous recombination (HR) DNA repair and maintaining chromosome integrity. To identify candidates that interact with HR proteins, the mouse RAD51C, RAD51D and XRCC2 proteins ...
A computational approach to inferring cellular protein-binding affinities from quantitative fluorescence resonance energy transfer imaging
(WILEY-VCH Verlag, 2009-12)
Fluorescence resonance energy transfer (FRET) microscopy can measure the spatial distribution of protein interactions inside live cells. Such experiments give rise to complex data sets with many images of single cells, ...
BiomarkerDigger: A versatile disease proteome database and analysis platform for the identification of plasma cancer biomarkers
(WILEY-VCH Verlag, 2009-07)
We have developed a proteome database (DB), BiomarkerDigger ( http://biomarkerdigger.org ) that automates data analysis, searching, and metadata-gathering function. The metadata-gathering function searches proteome DBs for ...
Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: Accurate detection of CA19-9 levels in pancreatic cancer
(WILEY-VCH Verlag, 2008-08)
The current study analyzed reverse phase protein arrays (RPPA) as a means to experimentally validate biomarkers in blood samples. One microliter samples of sera ( n 14= 1471), and plasma ( n 14= 1478) were serially diluted ...
Strategies for plasma proteomic profiling of cancers
(WILEY-VCH Verlag, 2006-10)
Despite a voluminous literature on potential protein biomarkers and a compelling need for diagnostic tests based on biomarkers to detect cancers at much earlier, more treatable stages, progress has been limited. New methods ...
Proteomic analysis of estrogen response of premalignant human breast cells using a 2-D liquid separation/mass mapping technique
(WILEY-VCH Verlag, 2006-07)
A 2-D liquid-phase separation method based on chromatofocusing and nonporous silica RP-HPLC followed by ESI-TOF-MS was used to analyze proteins in whole cell lysates from estrogen-treated and untreated premalignant, ...