Now showing items 11-20 of 59
Generalizing the TITE-CRM to adapt for early- and late-onset toxicities
(John Wiley & Sons, Ltd., 2005)
Due to the staggered entry of subjects in phase I trials, some subjects will only be partially through the study when others are ready to be enrolled. Nonetheless, many phase I designs focus solely upon whether or not ...
Semiparametric Bayesian modeling of random genetic effects in family-based association studies
(John Wiley & Sons, Ltd., 2009-01-15)
We consider the inference problem of estimating covariate and genetic effects in a family-based case-control study where families are ascertained on the basis of the number of cases within the family. However, our interest ...
Modelling tumour biology–progression relationships in screening trials
(John Wiley & Sons, Ltd., 2005)
There has been some recent work in the statistical literature for modelling the relationship between tumour biology properties and tumour progression in screening trials. While non-parametric methods have been proposed for ...
Confidence intervals of effect size in randomized comparative parallel-group studies
(John Wiley & Sons, Ltd., 2006-02-28)
We have presented a new likelihood-based approach for constructing confidence intervals of effect size that are applicable to small samples. We also conduct a simulation study to compare the coverage probability of the new ...
International Health Economics Association Seventeenth Annual Kenneth J. Arrow Award in Health Economics
(John Wiley & Sons, Ltd., 2008-09)
No Abstract
Stage-specific cancer incidence: An artificially mixed multinomial logit model
(John Wiley & Sons, Ltd., 2009-07-10)
Early detection of prostate cancer using the prostate-specific antigen test led to a sharp spike in the incidence of the disease accompanied by an equally sharp improvement in patient prognoses as evaluated at the point ...
Measurement of progression in Alzheimer's disease: a clinician's perspective
(John Wiley & Sons, Ltd., 2000-06-15)
Patients with Alzheimer's disease (AD) and their families must confront two fundamental truths. First, AD is a uniformly progressive disease that ultimately results in debilitating cognitive impairment. Second, although ...
Bias reduction for risk ratio and vaccine effect estimators
(John Wiley & Sons, Ltd., 2001-06-15)
We examine the structural bias for established estimators of vaccine effects on susceptibility and for newer estimates of vaccine effects on infectiousness. We then propose and analyse new bias corrections for vaccine ...
Genetic information, obesity, and labor market outcomes
(John Wiley & Sons, Ltd., 2008-09)
Economists have argued that obesity may lead to worse labor market outcomes, especially for women. Empirical methods to test this hypothesis have not thus far adequately controlled for the endogeneity of obesity. We use ...
Baseline patient characteristics and mortality associated with longitudinal intervention compliance
(John Wiley & Sons, Ltd., 2007-12-10)
Lin et al. ( http://www.biostatsresearch.com/upennbiostat/papers/ , 2006) proposed a nested Markov compliance class model in the Imbens and Rubin compliance class model framework to account for time-varying subject ...