Now showing items 51-60 of 1108
Excess mortality among 10‐year survivors of classical Hodgkin lymphoma in adolescents and young adults
(Wiley Periodicals, Inc., 2018-02)
Adolescents and young adults (AYA) surviving classical Hodgkin lymphoma (cHL) risk long term fatal treatment‐related toxicities. We utilized the Surveillance, Epidemiology and End Results (SEER) program to compare excess ...
Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element
(Wiley Subscription Services, Inc., A Wiley Company, 2009-08-15)
A classic morphogen, bone morphogenetic protein 2 (BMP2) regulates the differentiation of pluripotent mesenchymal cells. High BMP2 levels promote osteogenesis or chondrogenesis and low levels promote adipogenesis. BMP2 ...
A retrospective comparative outcome analysis following systemic therapy in Mycosis fungoides and Sezary syndrome
(Wiley Periodicals, Inc., 2016-12)
Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex
(Wiley Subscription Services, Inc., A Wiley Company, 2006-09-15)
Alterations of molecules that mediate dopaminergic signal transduction have been found in schizophrenia, supporting the hypothesis of altered dopaminergic neurotransmission in this illness. To further explore this hypothesis, ...
Genome‐Wide Family‐Based Linkage Analysis of Exome Chip Variants and Cardiometabolic Risk
(Wiley Periodicals, Inc., 2014-04)
Linkage analysis of complex traits has had limited success in identifying trait‐influencing loci. Recently, coding variants have been implicated as the basis for some biomedical associations. We tested whether coding ...
Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 mice
(Wiley Subscription Services, Inc., A Wiley Company, 2008-06)
Huntington's disease (HD) is a neurodegenerative disorder caused by an elongation of CAG repeats in the HD gene, which encodes a mutant copy of huntingtin with an expanded polyglutatmine repeat. Individuals who are ...
Methods for meta‐analysis of multiple traits using GWAS summary statistics
(Oxford University PressWiley Periodicals, Inc., 2018-03)
Genome‐wide association studies (GWAS) for complex diseases have focused primarily on single‐trait analyses for disease status and disease‐related quantitative traits. For example, GWAS on risk factors for coronary artery ...
The effect of mean and variance in resource supply on survival of annuals from Mediterranean and desert environments
(Springer-Verlag, 2004-10)
Resource availability is often characterized by mean annual amounts, while ignoring the spatial variation within habitats and the temporal variation within a year. Yet, temporal and spatial variation may be especially ...
Receptor-related interactions of opiates with PGE-induced adneylate cyclase in brain
(Elsevier, 2006-04-07)
The inhibition by opiates of the PGE2-induced formation of cAMP in slices from rat brain striatum was investigated. A maximal, 3.5-fold increase over the basal level of cAMP was obtained with an EC50 for PGE2 of 3 [mu]M. ...
Excitotoxic brain injury in adult zebrafish stimulates neurogenesis and long‐distance neuronal integration
(Wiley Periodicals, Inc., 2014-12)