Now showing items 33051-33060 of 33091
Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms
(Elsevier, 2016-03-01)
Amyotrophic lateral sclerosis is a late-onset and terminal neurodegenerative disease. The majority of cases are sporadic with unknown causes and only a small number of cases are genetically linked. Recent evidence suggests ...
Recombinant human erythropoietin stimulates melanoma tumor growth through activation of initiation factor eIF4E
(Impact Journals, 2017-01-01)
Recombinant human erythropoietin (EPO) is standard treatment for anemia in cancer patients. Recent clinical trials suggest that EPO may accelerate tumor progression and increase mortality. However, the evidence supporting ...
Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue
(Impact Journals, 2016-01-01)
Adipose tissue dysfunction in aging is associated with inflammation, metabolic syndrome and other diseases. We propose that impaired protein homeostasis due to compromised lysosomal degradation (micro-autophagy) might ...
Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging
(Impact Journals, 2017-09-01)
Adipose tissue (AT) inflammation is a central mechanism for metabolic dysfunction in both diet-induced obesity and age-associated obesity. Studies in diet-induced obesity have characterized the role of Fetuin A (Fet A) in ...
Gaps in Aging Research as it Applies to Rheumatologic Clinical Care
(Elsevier, 2017-02-01)
The incidence and prevalence of rheumatologic conditions are increasing and the rheumatology workforce must be aware of aging-specific issues. This article reviews specific barriers to understanding the biology of aging ...
Oxidative T Cell Modifications in Lupus and Sjogren's Syndrome.
(Longdom Group, 2017-04)
OBJECTIVES: Lupus flares are triggered by environmental agents that cause oxidative stress, but the mechanisms involved are unclear. The flares are characterized by oxidative modifications of proteins by 4-hydroxynonenals, ...
AUTOPHAGY ACTIVITY IS LINKED TO ELEVATED ER-STRESS AND INFLAMMATION IN AGING ADIPOSE TISSUE
(Oxford University Press (OUP), 2017-07-01)
Outbreak of murine infection with Clostridium difficile associated with the administration of a pre- and perinatal methyl donor diet
(American Society for Microbiology, 2019-03-01)
Between October 2016 and June 2017, a C57BL/6J mouse colony that was undergoing a pre- and perinatal methyl donor supplementation diet intervention to study the impact of parental nutrition on offspring susceptibility to ...