Now showing items 31-40 of 145
Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Caseâ Control Sequencing Studies
(Wiley Periodicals, Inc.Clarendon Press, 2016-09)
Rare variants (RVs) have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional singleâ marker methods for statistical ...
Next generation analytic tools for large scale genetic epidemiology studies of complex diseases
(University of ChicagoWiley Periodicals, Inc., 2012-01)
Over the past several years, genome‐wide association studies (GWAS) have succeeded in identifying hundreds of genetic markers associated with common diseases. However, most of these markers confer relatively small increments ...
Quantification of cytosolic plasmid DNA degradation using high‐throughput sequencing: implications for gene delivery
(Wiley Periodicals, Inc., 2014-03)
Background Although cytosolic DNA degradation plays an important role in decreasing transgene expression, the plasmid degradation pattern remains largely unexplored. Methods Illumina dye sequencing was employed to ...
Recommended Joint and Meta‐Analysis Strategies for Case‐Control Association Testing of Single Low‐Count Variants
(Chapman and HallWiley Periodicals, Inc., 2013-09)
In genome‐wide association studies of binary traits, investigators typically use logistic regression to test common variants for disease association within studies, and combine association results across studies using ...
Smoking and Genetic Risk Variation Across Populations of European, Asian, and African American Ancestry—A Meta‐Analysis of Chromosome 15q25
(Wiley Periodicals, Inc., 2012-07)
Identification of FAK substrate peptides via colorimetric screening of a one‐bead one‐peptide combinatorial library
(Wiley Periodicals, Inc., 2015-04)
Quantifying and correcting for the winner's curse in quantitative-trait association studies
(Wiley Subscription Services, Inc., A Wiley Company, 2011-04)
Quantitative traits (QT) are an important focus of human genetic studies both because of interest in the traits themselves and because of their role as risk factors for many human diseases. For large-scale QT association ...
Perinatal lead (Pb) exposure results in sex and tissue‐dependent adult DNA methylation alterations in murine IAP transposons
(Wiley Periodicals, Inc., 2017-10)