Now showing items 31-40 of 52
A Tale of Two RNAs: Single Molecule Investigation of the Conformation, Dynamics and Ligand Binding to the PreQ1 and T-box Riboswitches.
(2014)
Riboswitches are structured mRNA domains that can bind cellular metabolites and control gene expression of downstream genes mainly via transcription attenuation or inhibition of translation initiation. Although structures ...
Modeling Morphology Evolution for Nanostructured Electrochemical Systems.
(2015)
In this dissertation, we examine the morphological evolution of two nanostructured electrochemical systems, the growth of anodic alumina and the electrodeposition/electrodissolution of magnesium. These systems are investigated ...
Biophysical Approaches to Target Protein-Protein Interactions of Epigenetic Complexes by Small-Molecule Inhibitors
(2019)
Innumerable biological systems rely on Protein-Protein Interactions (PPIs) to govern basal physiological processes. Deregulation of PPIs is implicated in various human diseases, and PPIs have thus been frequently promoted ...
All-Electron Ground-State and Time-Dependent Density Functional Theory: Fast Algorithms and Better Approximations
(2019)
Density functional theory (DFT), in its ground-state as well as time-dependent variant, have enjoyed incredible success in predicting a range of physical, chemical and materials properties. Although a formally exact theory, ...
Nanopores with Fluid Walls for Characterizing Proteins and Peptides.
(2012)
Nanopore-based, resistive-pulse sensing is a simple single-molecule technique, is label free, and employs basic electronic recording equipment. This technique shows promise for rapid, multi-parameter characterization of ...
Investigations of Excited States and Radical Ions in ?-Conjugated Polymers of Interest for Photovoltaic Applications
(2017)
Photovoltaics using polymer semiconductors as active materials require donor/acceptor (D/A) interfaces to convert excitons into freed charges. In the absence of chain defects, excited states and charges migrate most ...
Development & Application of Constant pH Molecular Dynamics (CPHMD ) for Investigating pH-mediated Transient Conformational States and Their Effects on Nucleic Acid & Protein Activity.
(2015)
pH is a ubiquitous regulator of biological activity, with widespread impact ranging from its role in catalysis to carcinogenesis. Traditionally, a combination of biophysical and computational methods are used to measure ...
An Experimental Investigation of Premixed Combustion in Extreme Turbulence
(2017)
This work has explored various aspects of high Reynolds number combustion
that have received much previous speculation. A new high-Reynolds number
premixed Bunsen burner, called Hi-Pilot, was designed to produce ...
Spectroscopic Studies on the Molecular Structural Changes of Plastics and Plasticizers at Model Environmental Interfaces.
(2015)
The mainstream introduction of plastics poly(vinyl chloride) (PVC) and poly(styrene) (PS) has been integral to the formation of modern urban infrastructures and the advancement of medical, electronic, and industrial ...
Unsnarling Excitation, Relaxation and Scattering Dynamics in Multi-Chiral Distributions of Carbon Nanotubes
(2017)
This research begins the process of studying a polymer/carbon nanotube prototype solar cell. Inclusion of nanotubes in a photoactive polymer simultaneously overcomes the limited diffusion length of charge carriers and ...