Now showing items 11-20 of 42
Menin as a hub controlling mixed lineage leukemia
(WILEY‐VCH Verlag, 2012-09)
Mixed lineage leukemia (MLL) fusion protein (FP)‐induced acute leukemia is highly aggressive and often refractory to therapy. Recent progress in the field has unraveled novel mechanisms and targets to combat this disease. ...
Localized lentivirus delivery via peptide interactions
(Wiley Periodicals, Inc.InTech, 2016-09)
Gene delivery from biomaterial scaffolds has been employed to induce the expression of tissue inductive factors for applications in regenerative medicine. The delivery of viral vectors has been described as reflecting a ...
Mold‐casted non‐degradable, islet macro‐encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice
(Wiley Periodicals, Inc., 2016-11)
Islet transplantation is a potential cure for diabetic patients, however this procedure is not widely adopted due to the high rate of graft failure. Islet encapsulation within hydrogels is employed to provide a three‐dimensional ...
Dynamic microRNA activity identifies therapeutic targets in trastuzumab‐resistant HER2+ breast cancer
(Wiley Periodicals, Inc.Springer, 2018-10)
MicroRNAs (miRNAs) are implicated in numerous physiologic and pathologic processes, such as the development of resistance to chemotherapy. Determining the role of miRNAs in these processes is often accomplished through ...
Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease
(Wiley Periodicals, Inc., 2015-03)
Recreating the perivascular niche ex vivo using a microfluidic approach
(Wiley Subscription Services, Inc., A Wiley Company, 2010-12-15)
Stem cell niches are composed of numerous microenvironmental features, including soluble and insoluble factors, cues from other cells, and the extracellular matrix (ECM), which collectively serve to maintain stem cell ...
Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury
(Wiley Periodicals, Inc., 2019-01)
Spinal cord injury (SCI) results in paralysis below the injury and strategies are being developed that support axonal regrowth, yet recovery lags, in part, because many axons are not remyelinated. Herein, we investigated ...
Chaperone discovery
(WILEY‐VCH Verlag, 2012-11)
Molecular chaperones assist de novo protein folding and facilitate the refolding of stress‐denatured proteins. The molecular chaperone concept was coined nearly 35 years ago, and since then, tremendous strides have been ...
Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells
(Wiley Periodicals, Inc.Systems Biology, 2017-09)
The development of resistance to targeted therapeutics is a challenging issue for the treatment of cancer. Cancers that have mutations in BRCA, a DNA repair protein, have been treated with poly(ADP‐ribose) polymerase (PARP) ...
Pairing phosphoinositides with calcium ions in endolysosomal dynamics
(WILEY-VCH Verlag, 2011-06)
The direction and specificity of endolysosomal membrane trafficking is tightly regulated by various cytosolic and membrane-bound factors, including soluble NSF attachment protein receptors (SNAREs), Rab GTPases, and ...