Now showing items 381-385 of 385
Molecular Dynamics Simulation of Phase and Structural Transitions in Model Lung Surfactant Mixtures.
(2010)
Lung surfactant (LS) is a complex mixture of lipids and proteins that reduces and regulates the surface tension in the lungs, thereby decreasing the work of breathing. A thorough understanding of LS function is critical ...
Pharmaceutical Cocrystal Eutectic Analysis: Study of Thermodynamic Stability, Solubility, and Phase Behavior
(2010)
Cocrystals are an emerging solid-state form to change physicochemical and biopharmaceutical drug properties. This dissertation focuses on the thermodynamic stability and solubility of pharmaceutical cocrystals. Specifically, ...
Dendron Avidity Platforms with Orthogonal Focal Point Coupling Site.
(2010)
This thesis explores the design and synthesis of bifunctional or modular platforms from poly(amidoamine) (PAMAM) dendrons. PAMAM dendrons with an orthogonal focal point are evaluated, testing several click chemistry ...
Micro-hydrodynamics of deformable objects.
(2011)
We use a bead-spring model simulated by Brownian Dynamics (BD) with hydrodynamic interactions represented by the Rotne-Prager tensor, or simulated by Stochastic Rotation Dynamics (SRD) to study the dynamics of a wide range ...
Engineering the Quantitative PCR Assay for Decreased Cost and Complexity.
(2011)
The quantitative polymerase chain reaction (qPCR) is an assay of target nucleic acid concentration. Clinical applications of quantitative PCR include measurement of HIV viral load, measurement of bacterial infection, and ...