Now showing items 1-10 of 22
Retrievable hydrogels for ovarian follicle transplantation and oocyte collection
(American Cancer SocietyWiley Periodicals, Inc., 2018-08)
Cancer survivorship rates have drastically increased due to improved efficacy of oncologic treatments. Consequently, clinical concerns have shifted from solely focusing on survival to quality of life, with fertility ...
Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research
(Wiley Subscription Services, Inc., A Wiley Company, 2011-01)
Primary rat hepatocytes are a widely used experimental model to estimate drug metabolism and toxicity. In currently used two-dimensional (2D) cell culture systems, typical problems like morphological changes and the loss ...
Microprinted feeder cells guide embryonic stem cell fate
(Wiley Subscription Services, Inc., A Wiley Company, 2011-10)
We introduce a non‐contact approach to microprint multiple types of feeder cells in a microarray format using immiscible aqueous solutions of two biopolymers. Droplets of cell suspension in the denser aqueous phase are ...
Evaluation of encapsulating and microporous nondegradable hydrogel scaffold designs on islet engraftment in rodent models of diabetes
(Wiley Periodicals, Inc., 2018-09)
Islet transplantation is a promising therapeutic option for type 1 diabetes mellitus, yet the current delivery into the hepatic portal vasculature is limited by poor engraftment. Biomaterials have been used as a means to ...
A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells
(Wiley Subscription Services, Inc., A Wiley Company, 2010-11-01)
We have developed a bilayer microfluidic system with integrated transepithelial electrical resistance (TEER) measurement electrodes to evaluate kidney epithelial cells under physiologically relevant fluid flow conditions. ...
Assessing microbial competition in a hydrogen‐based membrane biofilm reactor (MBfR) using multidimensional modeling
(Cambridge University PressWiley Periodicals, Inc., 2015-09)
The membrane biofilm reactor (MBfR) is a novel technology that safely delivers hydrogen to the base of a denitrifying biofilm via gas‐supplying membranes. While hydrogen is an effective electron donor for denitrifying ...
Localized lentivirus delivery via peptide interactions
(Wiley Periodicals, Inc.InTech, 2016-09)
Gene delivery from biomaterial scaffolds has been employed to induce the expression of tissue inductive factors for applications in regenerative medicine. The delivery of viral vectors has been described as reflecting a ...
Mold‐casted non‐degradable, islet macro‐encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice
(Wiley Periodicals, Inc., 2016-11)
Islet transplantation is a potential cure for diabetic patients, however this procedure is not widely adopted due to the high rate of graft failure. Islet encapsulation within hydrogels is employed to provide a three‐dimensional ...
Dynamic microRNA activity identifies therapeutic targets in trastuzumab‐resistant HER2+ breast cancer
(Wiley Periodicals, Inc.Springer, 2018-10)
MicroRNAs (miRNAs) are implicated in numerous physiologic and pathologic processes, such as the development of resistance to chemotherapy. Determining the role of miRNAs in these processes is often accomplished through ...
Recreating the perivascular niche ex vivo using a microfluidic approach
(Wiley Subscription Services, Inc., A Wiley Company, 2010-12-15)
Stem cell niches are composed of numerous microenvironmental features, including soluble and insoluble factors, cues from other cells, and the extracellular matrix (ECM), which collectively serve to maintain stem cell ...