Now showing items 371-380 of 408
Targeting DNA Damage, Apoptosis, and the Cell Cycle for the Radiosensitization of Aggressive Forms of Breast Cancer
(2022)
Breast cancer is the most common invasive cancer diagnosed in women, and there is a critical need to identify novel treatment strategies. To that end, therapies designed to target molecular drivers specific to individual ...
Label Uncertainty and Learning Using Partially Available Privileged Information for Clinical Decision Support: Applications in Detection of Acute Respiratory Distress Syndrome
(2021)
Artificial intelligence and machine learning have the potential to transform health care by deriving new and important insights from the vast amount of data generated during routine delivery of healthcare. The digitization ...
Prioritization of Evolutionary Events for Immune Response Studies: Introgression, Selection, and Infectious Disease Among Indigenous Americans
(2020)
A history of exposure to infectious diseases has influenced the biology of Mesoamericans. From the urbanization of Mesoamerican communities to colonial contact in the 15th century, immune response to various pathogens have ...
Reducing Maternal Mortality and Morbidity in Michigan: A Mixed Methods Analysis of the Impact of an Obstetric Hemorrhage Patient Safety Bundle
(2022)
The United States has the highest rate of maternal mortality despite outspending all other resource-rich countries in per-capita reproductive health care. Contributing to this problem are a combination of factors including ...
Changes in Spending, Risk Selection, and the Response of Frontline Clinicians: Understanding Performance Mechanisms in the Medicare Shared Savings Program
(2021)
Confronted by an increasingly expensive and fragmented health care system, public and private payers have established a series of reforms designed to lower costs and improve quality. A leading example is the Medicare Shared ...
The Role of Aconitate Decarboxylase 1 in Inflammation and Disease
(2022)
Immune cell metabolism, or immunometabolism, has recently become of interest for its role in inflammation and disease. A growing field of research has identified that metabolic rewiring and immune cell activation are ...
Design and Testing Novel Wearable Instrumentation for Assessing Pelvic Floor Function and Exploring Continence Mechanisms
(2020)
Urinary incontinence (UI) and fecal incontinence (FI) affect 20% of North Americans, with a higher prevalence in women and the elderly. The prevention and treatment of these conditions unfortunately leaves much to be ...
Analysis of Trastuzumab (Tzb) Sensitivity in HER2+ PTEN-Deficient Breast Cancer Using Single Cell RNA-Seq
(2020)
HER2+ breast cancer is marked by the overexpression and/or amplification of the HER2 protein or HER2 gene, respectively. Current standard of care is trastuzumab-based therapy, but resistance remains a huge hurdle for ...
Ultrafast Microfluidic Immunoassays Towards Real-time Intervention of Cytokine Storms
(2020)
Biomarker-guided precision medicine holds great promise to provide personalized therapy with a good understanding of the molecular or cellular data of an individual patient. However, implementing this approach in critical ...
The Impact of Child and Adult Stressors on Multiple Sclerosis Biopsychosocial Disease Features
(2022)
Background: Multiple Sclerosis (MS) is a neuroinflammatory demyelinating autoimmune disease of the central nervous system that disproportionately affects people in North America. Although the etiology and cure remain ...