Now showing items 41-50 of 130
Comparison of Proteomic Assessment Methods in Multiple Cohort Studies
(Humana PressWiley Periodicals, Inc., 2020-06)
Effects of stereoisomeric structure and bond location on the ignition and reaction pathways of hexenes
(Wiley Periodicals, Inc., 2021-02)
The current work presents new experimental autoignition and speciation data on the two cis- hexene isomers: cis- 2- hexene and cis- 3- hexene. The new data provide insights on the effects of carbon- carbon double ...
Electrodynamic Force, Casimir Effect, and Stiction Mitigation in Silicon Carbide Nanoelectromechanical Switches
(ElsevierWiley Periodicals, Inc., 2020-12)
Logic switches enabled by nanoelectromechanical systems (NEMS) offer abrupt on/off- state transition with zero off- state leakage and minimal subthreshold swing, making them uniquely suited for enhancing mainstream ...
Frontispiz: Diverse Nanoassemblies of Graphene Quantum Dots and Their Mineralogical Counterparts
(Wiley Periodicals, Inc., 2020-05-25)
A novel method of high‐purity extracellular vesicle enrichment from microliter‐scale human serum for proteomic analysis
(Endotext, MDText.com, Inc.Wiley Periodicals, Inc., 2021-02)
We have developed a rapid, low‐cost, and simple separation strategy to separate extracellular vesicles (EVs) from a small amount of serum (i.e.,<100 μL) with minimal contamination by serum proteins and lipoprotein particles ...
The pH- Induced Selectivity Between Cysteine or Histidine Coordinated Heme in an Artificial α- Helical Metalloprotein
(SpringerWiley Periodicals, Inc., 2021-02-19)
De Novo metalloprotein design assesses the relationship between metal active site architecture and catalytic reactivity. Herein, we use an α- helical scaffold to control the iron coordination geometry when a heme cofactor ...
Making or Breaking Metal- Dependent Catalytic Activity: The Role of Stammers in Designed Three- Stranded Coiled Coils
(Wiley Periodicals, Inc.ACS Publications, 2020-11-09)
While many life- critical reactions would be infeasibly slow without metal cofactors, a detailed understanding of how protein structure can influence catalytic activity remains elusive. Using de novo designed three- ...
Hydrazone and Oxime Olefination via Ruthenium Alkylidenes
(Wiley, 2022-05-23)
We describe the development of an efficient method for the olefination of hydrazones and oximes. The key design approach that enables this transformation is tuning of the energy/polarity of C=N π-bonds by employing heteroatom ...
A Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing
(Wiley Periodicals, Inc., 2022-04)
Diabetic wound treatment faces significant challenges in clinical settings. Alternative treatment approaches are needed. Continuous bleeding, disordered inflammatory regulation, obstruction of cell proliferation, and ...
Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo
(Wiley Periodicals, Inc.W.H. Freeman & Co Ltd, 2022-03)
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which enable functional intracellular delivery. ...