Now showing items 1-10 of 32
Chronic haloperidol treatment increased calcium-dependent phosphorylation in rat striatum
(Elsevier, 1982-01-04)
In previous studies, we observed that when rats were chronically treated with haloperidol, there was a significant increase of calmodulin activity in their striatal membranes. Calmodulin is knwon to modulate calcium-dependent ...
Linkage of the structural gene for uroporphyrinogen I synthase to markers on mouse chromosome 9 in a cross between feral and inbred mice
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1982-08)
The Ups locus has been mapped to mouse chromosome 9 in a three-point cross. The observed gene order is centromere- Ups -15- Mpi-1 -22- Mod-1 . Ups is unlinked to Lv , which encodes the previous enzyme in the heme biosynthesis ...
Role of isosafrole as complexing agent and inducer of P-450LM4 in rabbit liver microsomes
(Elsevier, 1982-09-16)
Isosafrole serves as an excellent inducing agent in rabbits for P-450LM4, the same isozyme as that which is induced by 3-methylcholanthrene and 5,6-benzoflavone. Since the isosafrole adduct formed with isozyme 4 is unstable, ...
Michael addition of thiols with 4-methyleneglutamic acid: Preparation of adducts, their properties and presence in peanuts
(Elsevier, 1982-04-29)
The thioethers, S-(4-amino-2,4-dicarboxybutyl)cysteamine, S-(4-amino-2,4-dicarboxybutyl)cysteine and S-(4-amino-2,4-dicarboxybutyl)glutathione, were synthesized by a Michael addition between 4-methyleneglutamic acid and ...
Teratogenic action of platinum thymine blue
(Elsevier, 1982-08-23)
The teratogenic activity of the antitumor agent cisplatinum-2-thymine (platinum thymine blue) was investigated in rats. Pregnant Wistar-derived albino rats were given single ip injections of an aqueous solution of platinum ...
Isolation of chromosome clusters from metaphase-arrested HeLa cells
(Springer-Verlag, 1982-08)
We have developed a simplified approach for the isolation of metaphase chromosomes from HeLa cells. In this method, all the chromosomes from a cell remain together in a bundle which we call a “metaphase chromosome cluster”. ...
Visualization of opiate receptors and opioid peptides in sequential brain sections
(Elsevier, 1982-09)
Autoradiographic and immunocytochemical studies were carried out on adjacent sections from formaldehyde-perfused rat brains in order to directly correlate the distribution of opiate receptors and opioid peptides. Perfusion ...
Increase in delta, but not mu, receptors in MSG-treated rats
(Elsevier, 1982-09)
Neonatal treatment of rats with Monosodium Glutamate (MSG) has been demonstrated to destroy cell bodies of neurons in the arcuate nucleus including the brain beta-endorphin (B-END) system. The effects on opiate receptors ...
The effect of gentamicin on calcium uptake by renal mitochondria
(Elsevier, 1982-06-28)
The effect of the nephrotoxic aminoglycoside antibiotic, gentamicin, on calcium uptake by renal cortical mitochondria was assessed in vitro. Gentamicin was found to be a competitive inhibitor of mitochondrial Ca++ uptake. ...