Now showing items 41-50 of 50
In vivo binding of [18F]GBR 13119 to the brain dopamine uptake system
(Elsevier, 1988)
Regional rat brain uptake of [18F]GBR 13119, a high specific activity, positron-emitter labeled derivative of the potent dopamine uptake antagonist GBR 12935, is reported. Striatum to cerebellum ratios of 3 are obtained ...
Characteristics of the membrane of the stereocilia and cell apex in cochlear hair cells
(Kluwer Academic Publishers; Chapman and Hall Ltd ; Springer Science+Business Media, 1988-06)
Freeze-fracture has been used to examine the membrane of the cell apex and of the stereocilia in cochlear hair cells. The apical (non-stereociliary) membrane of inner hair cells (IHCs) exhibited a lower density of intramembrane ...
Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: Development of a ligard with high delta opioid receptor selectivity and affinity
(Elsevier, 1988)
Tetrapeptides of primary sequence Tyr-X-Phe-YNH2, where X is D-Cys or D-Pen (penicillamine) and where Y is D-Pen or L-Pen, were prepared and were cyclized via the side chain sulfurs of residues 2 and 4 to disulfide or ...
Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene
(Elsevier, 1988-01-15)
Two genes that hybridize to the cDNA for alcohol-inducible cytochrome P-450 form 3a (P-450ALC) have been isolated from a rabbit genomic library and characterized by restriction mapping, hybridization, and partial sequence ...
Structure of human serum cholinesterase
(Wiley Subscription Services, Inc., A Wiley Company, 1988-10)
Human cholinesterase has recently been sequenced and cloned. It is a glycoprotein of 4 identical subunits, each subunit containing 9 carbohydrate chains and 3.5 disulfide bonds. Protein folding is likely to be very ...
Interstitial water patterns: A factor influencing the distributions of some lotic aquatic vascular macrophytes
(Elsevier, 1988-07)
The distributions of 9 species of aquatic vascular macrophytes were examined in relation to interstitial water patterns (based on temperature) in the beds of three northern Michigan (U.S.A.) streams. Ranunculus septentrionalis ...
Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline
(Elsevier, 1988-09-30)
Tumor necrosis factor-alpha (TNF), a mononuclear phagocyte (MO)-derived peptide, is increasingly being recognized for its pleomorphic immunologic effects. A number of investigations have demonstrated that lipopolysaccharide ...
Near stoichiometric, irreversible inactivation of bacterial collagenases by o-chloranil (3,4,5,6-tetrachloro-1,2-benzoquinone)
(Elsevier, 1988-05-31)
SummaryThe hydrogen-abstracting quinone derivative 3,4,5,6-tetrachloro-1,2-benzoquinone (o-chloranil) caused a strong, near stoichiometric, irreversible inactivation of the collagenases from Bacillus cereus, Clostridium ...
Bright artificial light produces subsensitivity to nicotine
(Elsevier, 1988)
Bright artificial light is a treatment for seasonal depression. Eleven (11) rats were exposed to bright artificial light (11,500 lux) for two consecutive weeks. The thermic response to nicotine was measured prior to light ...