Now showing items 61-70 of 136
A comparison of benzodiazepine, serotonin, and dopamine agents in the taste-reactivity paradigm
(Elsevier, 1990-11)
Previous studies have shown that ra'ss positive, palatability-dependent consummatory reactions to infused tastes are selectively facilitated by a benzodiazepine agonist (chlordiazepoxide), and that this effect can be blocked ...
Characterization of the intestinal transport parameters for small peptide drugs
(Elsevier, 1990-08)
Several laboratories have recently shown that many peptides and peptide-similar drugs are well absorbed in the mammalian intestine via the peptide transport system for nutrient small peptide (dipeptides and tripeptides) ...
Synthesis of indolidines by the 1,3-dipolar cycloaddition of azides with methylenecyclopropanes followed by cyclopropyumine rearrangement
(Elsevier, 1990)
Cyclic imines 6a and 6b were obtained by the intramolecular 1,3-dipolar cycloaddition of azides with methylenecyclopropanes. Acid catalyzed rearrangement produced bicyclic (-)-enamines 7, which upon reduction provided ...
Activation of human T cell clones through the UM4D4/CDw60 surface antigen
(Elsevier, 1990-07)
UM4D4 is a recently defined antigen that is expressed on ~25% of peripheral blood T cells, but on the majority of T cells in inflammatory synovial fluid. Anti-UM4D4 activates peripheral blood T cells in the presence of ...
The intramolecular cycloaddition of azides with [omega]-chloroalkenes. A facile route to (+/-)-swainsonine and other indolizidine alkaloids
(Elsevier, 1990)
A potentially general route to the 1-azabicyclo[n.m.O]alkane skeleton of various alkaloids is embodied in the intramolecular 1,3-dipolar cycloaddition of aliphatic azides with [omega]-chloroalkenes. Cycloaddition is followed ...
Expression of erbA[alpha] and [beta] mRNAs in regions of adult rat brain
(Elsevier, 1990-03-26)
The proto-oncogenes erbAa and erbA[beta] together encode three functional thyroid hormone receptors (erbAol, [beta]1, and [beta]2), as well as two proteins (erbA[sigma] 2 and [alpha]3) that do not bind T3. The erbA[alpha]2 ...
The effects of pentoxifylline on lipopolysaccharide (LPS) fever, plasma interleukin 6 (IL 6), and tumor necrosis factor (TNF) in the rat
(Elsevier, 1990-07)
The purpose of these studies was to test whether pentoxifylline, a drug that can inhibit the production and action of cytokines hypothesized to be endogenous pyrogens (for example, interleukin 1 and tumor necrosis factor ...
In Vitro release of hypothalamic [beta]-endorphin [beta]E by arginine vasopressin, corticotropin-releasing hormone and 5-hydroxytryptamine: Evidence for release of opioid active and inactive [beta]E forms
(Elsevier, 1990-05)
The aims of the present experiments were: 1) to test whether substances which modulate beta-endorphin-immunoreactive [beta]E-ir release from the pituitary gland might act similarly in hypothalamic tissue; and 2) to further ...
Laboratory properties of cold-adapted influenza B live vaccine strains developed in the US and USSR, and their B/Ann Arbor/1/86 cold-adapted reassortant vaccine candidates
(Elsevier, 1990-02)
The adaptation of two influenza B strains (B/Leningrad/14/55 and B/Ann Arbor/1/66) to replication at 25[deg]C is described. Comparison of the two viruses indicates that both also exhibit temperature sensitive phenotypes, ...
Identification of a sheath-associated protein involved in phosphate transport in Sphaerotilus natans
(Springer-Verlag, 1990-11)
Sphaerotilus natans was shown to have a fourfold lower K′ m of phosphate transport when grown in medium containing 0.1 m m phosphate, compared to cells grown in 10.0 m m phosphate. Analysis of sheath proteins from cells ...