Now showing items 131-140 of 158
Phase II evaluation of piroxantrone in renal cell carcinoma
(Kluwer Academic Publishers; Springer Science+Business Media, 1992-06)
The Southwest Oncology Group (SWOG) studied the response rate and toxicity of piroxantrone (150 mg/m 2 q 21 days) in patients with advanced metastatic renal cell carcinoma. Among 32 eligible patients, there were no partial ...
A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus
(Elsevier, 1992-11)
We describe a high-resolution radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 (NF2) gene. Eighty-five hamster--human somatic cell hybrids generated by X-irradiation and ...
An SV40 transformation revertant due to a host mutation: Isolation and complementation analysis
(Elsevier, 1992-04)
We have isolated an SV40 transformation revertant cell line, CLi L, by selection for normal cells whose growth is inhibited under low serum conditions. This line expresses a single, wild-type copy of large T antigen, yet ...
Detection of genetic heterogeneity for complex quantitative phenotypes
(Wiley Subscription Services, Inc., A Wiley Company, 1992)
Statistically characterizing factors responsible for quantitative phenotype expression (e.g., polygenes, major genes, shared household factors, etc.) through model selection strategies is a difficult task. A great deal of ...
The role of deoxycytidine-metabolizing enzymes in the cytotoxicity induced by 3′-amino-2′,3′-dideoxycytidine and cytosine arabinoside
(Springer-Verlag, 1992-03)
The cellular metabolism of 3′-amino-2′,3′-dideoxycytidine (3′-NH 2 -dCyd), a cytotoxic agent previously reported to be a poor substrate for purified Cyd/dCyd deaminase (dCydD), was compared with that of cytosine arabinoside ...
Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7
(Elsevier, 1992-09)
A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is part of a human-mouse ...
Vibrational studies of the disulfide group in proteins. VII. Normal mode analysis of the Raman spectra of erabutoxin, γ‐II crystallin and immunoglobulin
(John Wiley & Sons, Ltd., 1992-10)
Normal mode calculations have been made on the known structures of disulfide bridges in erabutoxin b, a form of γ‐II crystallin, and fragments (Fab, variable‐domain of Bence‐Jones proteins) of immunoglobulins. Previously ...
Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells
(Elsevier, 1992-01)
In SK-N-SH human neuroblastoma cells, the muscarinic agonist carbachol promotes polyphosphoinositide (PPI) hydrolysis via M3 receptors and increases cyclic AMP levels through an unidentified mechanism. Activation of PPI ...
The relationship between saccharin and alcohol intake in rats
(Elsevier, 1992)
Male rats were given daily sessions during which a palatable saccharin solution was available. Based on intakes averaged over 3 days, groups with low, intermediate, or high intake of saccharin were formed. These rats were ...
Extended pedigree patterned covariance matrix mixed models for quantitative phenotype analysis
(Wiley Subscription Services, Inc., A Wiley Company, 1992)
Overt computational constraints in the formation of mixed models for the analysis of large extended-pedigree quantitative trait data which allow one to reliably characterize and partition sources of variation resulting ...