Now showing items 81-90 of 158
Development and utilization of a somatic cell hybrid mapping panel to assign NotI linking probes to the long arm of human chromosome 6
(Elsevier, 1992-03)
A somatic cell hybrid mapping panel that defines seven regions of the long arm and one region of the short arm of human chromosome 6 has been developed. Utilizing this panel, 17 NotI boundary clones from a NotI linking ...
CD45 modulates T cell receptor/CD3-induced activation of human thymocytes via regulation of tyrosine phosphorylation
(WILEY-VCH Verlag GmbH, 1992-02)
Stimulation of thymocytes or mature T cells via the T cell receptor (TcR)/CD3 complex activates a cascade of processes inducing cells to enter the cell cycle. A key step is the activation of phosphatidylinositol-specific ...
On the factors that affect the mode of cyclization of [alpha]-silyl radicals: A method for angular hydroxymethylation by the 5-exo cyclization
(Elsevier, 1992-10-27)
The steric and stereochemical factors which favor the 5-exo cyclization of a 5-substituted 2-sila-5-hexen-1-yl radical have been probed. This radical cyclization approach constitutes a highly efficient and convenient means ...
Inhibition of organic anion transport in endothelial cells by hydrogen peroxide
(Elsevier, 1992-11-01)
ATP loss is a prominent feature of cellular injury induced by oxidants or ischemia. How reduction of cellular ATP levels contributes to lethal injury is still poorly understood. In this study we examined the ability of ...
Lectin-based homogeneous enzyme-linked binding assay for estimating the type and relative amount of carbohydrate within intact glycoproteins
(Elsevier, 1992-04)
The feasibility of using a new lectin-based homogeneous enzyme-linked binding assay for estimating the type and relative amount of specific carbohydrate structures within intact glycoproteins is examined. Malate ...
Insertional mutation of `classical' and novel genes in transgenic mice
(Elsevier, 1992-10)
Approximately 5% of established transgenic lines carry insertional mutations. The mutated genes may be directly isolated using the transgene DNA as a molecular probe. These mutants provide useful models of human inherited ...
Quantitative autoradiographic evaluation of the influence of protein dose on monoclonal antibody distribution in human ovarian adenocarcinoma xenografts
(Springer-Verlag, 1992-11)
We studied the effect of monoclonal antibody protein dose on the uniformity of radioiodinated antibody distribution within tumor masses using quantitative autoradiography. Groups ( n = 11–13/group) of athymic nude mice ...
Molecular and electrophysiological characterization of a allelic variant of the rat [alpha]6 GABAA receptor subunit
(Elsevier, 1992-11)
A 1.45 kb DNA sequence encoding the rat [alpha]6 GABAA receptor subunit (nucleotides 33-1483) was clonedfrom a Sprague-Dawley rat brain cDNA library by PCR amplification. Dideoxy sequencing of two individual clones revealed ...
Design, synthesis and activity against human cytomegalovirus of non-phosphorylatable analogs of toyocamycin, sangivamycin and thiosangivamycin
(Elsevier, 1992-12)
A number of 7-alkyl 4-aminopyrrolo[2,3-pyrimidine derivatives related to toyocamycin, sangivamycin and thiosangivamycin have been prepared and tested for their activity against human cytomegalovirus (HCMV). Only the thioamide ...
Phase II trial of N-methylformamide in lung cancer
(Kluwer Academic Publishers; Springer Science+Business Media, 1992-08)