Now showing items 131-140 of 152
High yield synthesis of high specific activity R-(-)-[11C]epinephrine for routine PET studies in humans
(Elsevier, 1993-11)
R-(-)-[11C]Epinephrine ([11C]EPI) has been synthesized from R-(-)-norepinephrine by direct methylation with [11C]methyl iodide or [11C]methyl triflate. The total synthesis time including HPLC purification was 35-40 min. ...
Characterization of the Left 4 kb of Conjugative Transposon Tn916: Determinants Involved in Excision
(Elsevier, 1993-11)
The rate-limiting step in movement of the conjugative transposon Tn916, originally identified in Enterococcus faecalis, is believed to be an excision event that generates a non-replicative circular intermediate. When present ...
Junctional diversification in the generation of the precursor of a discrete immune response
(Elsevier, 1993-03)
Phosphocholine (PC)-specific antibodies that arise in the mouse in response to Proteus morganii (PM) and use V1-DFL16.1-JH1 are characterized by a number of recurring mutations. Most striking is an invariant A for G ...
An Anti-CD2 Monoclonal Antibody That Both Inhibits and Stimulates T Cell Activation Recognizes a Subregion of CD2 Distinct from Known Ligand-Binding Sites
(Elsevier, 1993-09)
The T lymphocyte glycoprotein CD2 appears to have an important role in human T cell development and activation. A novel anti-CD2 monoclonal antibody, designated UMCD2, was shown to block E rosetting, and therefore was ...
Biochemical production capabilities of escherichia coli
(Wiley Subscription Services, Inc., A Wiley Company, 1993-06-05)
Microbial metabolism provides at mechanism for the conversion of substrates into useful biochemicals. Utilization of microbes in industrial processes requires a modification of their natural metabolism in order to increase ...
Immunization of institutionalized asthmatic children and patients with psychomotor retardation using live attenuated cold-adapted reassortment influenza A H1N1, H3N2 and B vaccines
(Elsevier, 1993)
Live attenuated cold-adapted reassortant (CR) influenza virus vaccines were evaluated in institutionalized asthmatic children and severe psychomotor-retarded (SPR) patients. Almost all the vaccines were seropositive to the ...
Expression, Purification, and Binding Properties of Human Cellular Retinoic Acid-Binding Protein Type I and Type II
(Elsevier, 1993-02-01)
Human cellular retinoic acid-binding protein (CRABP) type I and type II were expressed in Escherichia coli from cloned cDNAs. Expressed proteins were purified by gel filtration and ion-exchange chromatography, resulting ...
Diurnal Regulation of Glucocorticoid Receptor and Mineralocorticoid Receptor mRNAs in Rat Hippocampus
(Elsevier, 1993-04)
The present studies were undertaken to determine whether hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) biosynthesis, as inferred from mRNA expression, exhibit diurnal patterns of activation ...
Phosphorylation of neuromodulin in rat striatum after acute and repeated, intermittent amphetamine
(Elsevier, 1993-12)
Repeated, intermittent treatment of rats with amphetamine results in a sensitization of locomotor and stereotyped behaviors that is accompanied by an enhancement in stimulus-induced dopamine release. Increased phosphorylation ...
Age-Associated Decline in IL-4 Production by Murine T Lymphocytes in Extended Culture
(Elsevier, 1993-10-01)
Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBIo, CD44bi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this ...