Now showing items 11-20 of 108
Studies on morpholinosphingolipids: Potent inhibitors of glucosylceramide synthase
(Elsevier, 1994-04-25)
Synthetic 1-morpholino-1-deoxyceramides were designed to inhibit glucosylceramide synthase. The most potent inhibitor 2a possesses the unnatural R,R-configuration of D-threo-sphingosine.
Selective effect of alcohol on cellular immune responses of lymphocytes from AIDS patients
(Elsevier, 1994)
In this study we examined the in vitro effects of alcohol on the proliferative responses of lymphocytes from healthy donors and AIDS patients to a recombinant fusion peptide, env-gag, corresponding to portions of the gp ...
Off-diagonal disorder model for exciton polaritons in layered media. Disorder-induced origin of radiative widths
(Elsevier, 1994-10-07)
Excitons in an infinite layered dipolar medium, such as a layered crystal or a multiple-quantum-well stack, with perfect periodicity exhibit a vanishing radiative width due to the requirement of energy-momentum conservation. ...
A formal and enantioselective synthesis of (-)-serricornin, the sex pheromone of the cigarette beetle (lasioderma serricorne F.)
(Elsevier, 1994-04)
A synthesis of (-)-Serricornin is described. The (4S,5S)-4-methyl-5-ethyl [delta]-valerolactone 8 has been synthesized with a high degree of enantioselectivity starting from (R)-(+)-(E)-1-propenyl p-tolylsulfoxide 2, having ...
Direct optical resolution of vesamicol and a series of benzovesamicol analogues by high-performance liquid chromatography
(Elsevier, 1994-04-29)
The direct optical resolution of the vesicular acetylcholine uptake inhibitors vesamicol and benzovesamicol and nine benzovesamicol analogues were performed by HPLC on a commercially available cellulose tris(3,5-dimethylphenyl ...
Iodine-promoted decomposition of 1-aryl-3,3-dialkyltriazenes: A mild method for the synthesis of aryl iodides
(Elsevier, 1994-08-01)
Iodine promoted decomposition of 1-aryl-3,3-dialkyltriazenes in organic solvents is shown to give high yields of the corresponding aryl iodides under extremely mild conditions. The presence of iodine greatly accelerates ...
Modulation of opioid signal transduction in SH-SY5Y neural cells by differentiating agents: Concurrent mu receptor upregulation and effector desensitization by phorbol ester
(Elsevier, 1994-02-21)
Long-term exposure of SH-SY5Y human neural cells to retinoic acid (RA) increased the binding of [3H]DAMGO and [3H]DPDPE by up to 3-fold compared to membranes of untreated cells. In contrast, incubation of the cells with ...
Expression of Wild-Type and Mutant Rat Liver CTP: Phosphocholine Cytidylyltransferase in a Cytidylyltransferase-Deficient Chinese Hamster Ovary Cell Line
(Elsevier, 1994-05)
The strain 58 Chinese hamster ovary (CHO) mutant defective in CTP:phosphocholine cytidylyltransferase was characterized as an expression system for exogenous cytidylyltransferase. Strain 58 cells express less than 5% of ...
Synthesis and assignments of regioisomeric cyanoimidazole esters
(Elsevier, 1994-02-28)
Regioassignments of ethyl cyanoimidazolecarboxylates have been performed by the nuclear Overhauser effect(NOE) studies on the regioisomeric monocyanoimidazoles obtained by the hydrolysis of the esters followed by ...
Synthesis of (+/-)tylophorine by the intramolecular cycloaddition of an azide with an [omega]-chloroalkene
(Elsevier, 1994)
Cyclization of (Z)-1-(2-chloromethyl)phenyl-5-azidopent-1-ene 10 in benzene at 120[deg]C followed by treatment with sodium borohydride produced 1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinoline 11 in 71% yield. A similar ...