Now showing items 171-179 of 179
DNA Sequences in the Promoter Region of the NF1 Gene Are Highly Conserved between Human and Mouse
(Elsevier, 1994-06)
The gene for type 1 neurofibromatosis (NF1) is most highly expressed in brain and spinal cord, although low levels of mRNA can be found in nearly all tissues. As a first step in investigating the regulation of NF1 gene ...
Pharmacophore elements of the TIPP class of delta opioid receptor antagonists
(Kluwer Academic Publishers; ESCOM Science Publishers B.V. ; Springer Science+Business Media, 1994-10)
A series of tri-and tetrapeptides sharing the amino-terminal dipeptide unit Tyr-Tic, found in the high-affinity delta opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP), was prepared and evaluated in receptor binding assays ...
Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists
(Springer-Verlag, 1994-05)
The discriminative stimulus effects of several μ-opioid agonists were examined under conditions of opioid sensitization or tolerance, i.e., before and after 1-week SC infusions of naloxone or μ-opioid agonists. Rats were ...
Nucleotide Sequence of the 18-kb Conjugative Transposon Tn916 from Enterococcus faecalis
(Elsevier, 1994-11)
Conjugative transposon Tn916 from Enterococcus faecalis DS16 encodes tetracycline resistance (Tet M) as well as determinants necessary for its own movement. Determination of the nucleotide sequence of Tn916 has been ...
VCAM-1 influences Lymphocyte Proliferation and Cytokine Production during Mixed Lymphocyte Responses
(Elsevier, 1994-03)
The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role of adherence molecule ...
A five-year multicenter study of the susceptibility of the Bacteroides fragilis group isolates to cephalosporins, cephamins, penicillins, clindamycin, and metronidazole in the United States
(Elsevier, 1994-04)
Over 2800 clinical strains of the Bacteroides fragilis group were collected during a 5-year period from ten geographically separate sites and tested for their susceptibility to various antimicrobial agents using a broth ...
Specific steroid response from a nonspecific DNA element
(Elsevier, 1994-06)
A fundamental dilemma of steroid hormone regulation is how specific transcription is attained in vivo when several receptors recognize the same DNA sequence in vitro. We have identified an enhancer of the mouse sex-limited ...