Now showing items 51-60 of 179
Chloroquine accumulation and alterations of proteolysis and pinocytosis in the rat conceptus in vitro
(Elsevier, 1994-02-11)
The teratogenicity of chloroquine (CQ) has been hypothesized to result from its effects on lysosomal function, specifically the ability of the visceral yolk sac (VYS) to capture and degrade external macromolecules. Using ...
Conserved Linkage of Early Growth Response 4, Annexin 4, and Transforming Growth Factor [alpha] on Mouse Chromosome 6
(Elsevier, 1994-01-15)
The mouse genes encoding early growth response 4 (Egr4), annexin IV (Anx4), and transforming growth factor a (Tgfa) have been mapped to a linkage group on mouse chromosome 6 that is conserved on human chromosome 2p11-p13. ...
Frequent harvesting from perfused bone marrow cultures results in increased overall cell and progenitor expansion
(Wiley Subscription Services, Inc., A Wiley Company, 1994-08-20)
The establishment of prolific long-term human bone marrow cultures has led to the development of hematopoietic bioreactor systems. A single batch expansion of bone marrow mononuclear cell populations leads to a 10- to ...
Microencapsulated human bone marrow cultures: A potential culture system for the clonal outgrowth of hematopoietic progenitor cells
(Wiley Subscription Services, Inc., A Wiley Company, 1994-04-05)
Currently the most successful methods for culturing human hematopoietic cells employ some form of perfused bioreactor system. However, these systems do not permit the clonal outgrowth of single progenitor cells. Therefore, ...
Alkylation of proteins by artemisinin : Effects of heme, pH, and drug structure
(Elsevier, 1994-08-03)
Artemisinin and its derivatives are a promising new class of antimalarial agents containing an endoperoxide bridge. [14C]Artemisinin alkylated various proteins in vitro. Between 5 and 18% of added drug bound to hemoproteins ...
The structure and function of supported molybdenum nitride hydrodenitrogenation catalysts
(Elsevier, 1994-03)
A series of [gamma]-Al2O3 supported Mo nitrides were prepared by the temperature programmed reaction of supported molybdates with NH3. Several loadings, heating rates, and space velocities were employed in an attempt to ...
An Integrated Physical Map of 210 Markers Assigned to the Short Arm of Human Chromosome 11
(Elsevier, 1994-06)
Using a panel of patient cell lines with chromosomal breakpoints, we constructed a physical map for the short arm of human chromosome 11. We focused on 11p15, a chromosome band harboring at least 25 known genes and associated ...
Differential expression of metabotropic glutamate receptors in the hippocampus and entorhinal cortex of the rat
(Elsevier, 1994-02)
Metabotropic glutamate receptors (mGluRs) have been implicated in a number of hippocampal functions including learning and memory. Five subtypes have been molecularly and pharmacologically characterized. Using in situ ...