Now showing items 21-30 of 40
Prediction of blood-brain partitioning using Monte Carlo simulations of molecules in water
(Kluwer Academic Publishers; Springer Science+Business Media, 2001-08)
The brain-blood partition coefficient (log BB ) is a determining factor for the efficacy of central nervous system acting drugs. Since large-scale experimental determination of log BB is unfeasible, alternative evaluation ...
Digital signal processing and zero-dead-time counting
(Kluwer Academic Publishers; Kluwer Academic Publishers/Akadémiai Kiadó ; Springer Science+Business Media, 2001-05)
One of the most recent developments in equipment for high and/or varying count rates, as encountered in the gamma-ray spectrometry needed for INAA via short-lived radionuclides, is the advent of EG&G Ortec's DSPECplus™. ...
Multiple-Well, multiple-path unimolecular reaction systems. II. 2-methylhexyl free radicals
(John Wiley & Sons, Inc., 2001-04)
Vibrationally excited 2-methylhexyl radicals formed by shock wave activation or by chemical activation can isomerize by multiple pathways to form any of six stable isomers, can fragment by multiple C[bond]H and C[bond]C ...
Conjugation of 5′‐Functionalized Oligodeoxyribonucleotides with Properly Functionalized Ligands
(IRL PressWiley Periodicals, Inc., 2001-12)
This unit reports the synthesis of oligodeoxyribonucleotides covalently linked via their 5′ termini to various ligands such as intercalating agents, reactive groups, or labels. Methods for incorporation of halogenoalkyl, ...
Rapid Magnesium Chelation as a Method to Study Real‐Time Tertiary Unfolding of RNA
(Wiley Periodicals, Inc.MIT Press, 2001-09)
This unit describes a method to measure the unfolding of RNA tertiary structure on a millisecond time scale. A stopped‐flow spectrophotometer is used to measure the rate of unfolding induced by the addition of EDTA to an ...
Retention behavior of large polycyclic aromatic hydrocarbons on metalloprotoporphyrin-silica stationary phases
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2001-02)
The retention behavior of large polycyclic aromatic hydrocarbons (LPAHs) (≥ 7 rings) on newly developed metalloprotoporphyrin (MProP)-silica stationary phases is examined and the results are compared to previously reported ...
Morphological evolution of thick wax deposits during aging
(Wiley Subscription Services, Inc., A Wiley Company, 2001-01)
The presence of waxes in crude oil can lead to the formation of wax deposits on the walls of cold subsea pipelines, which restricts flow and can lead to plugging of the pipelines. This problem has recently become more ...
Regioselective 2′‐Silylation of Purine Ribonucleosides for Phosphoramidite RNA Synthesis
(Wiley Periodicals, Inc., 2001-09)
This unit describes high‐yield procedures for protection of purine ribonucleosides based on a reaction that allows concomitant highly regioselective 2′‐silylation and 3′‐phosphitylation to give, in one step, monomers that ...
Time‐Resolved Hydroxyl Radical Footprinting of RNA with X‐Rays
(Wiley Periodicals, Inc.Practical Applications., 2001-09)
RNA tertiary structure and protein interactions can be detected by protection from hydroxyl radical cleavage. Generation of hydroxyl radicals with a synchrotron X‐ray beam provides analysis on a short timescale (50 msec ...
Modification of the 5′ Terminus of Oligodeoxyribonucleotides for Conjugation with Ligands
(Wiley Periodicals, Inc.IRL Press, 2001-07)
Ligands can be introduced at the 5′ terminus of an oligonucleotide by adding a linker to the ligand and modifying the 5′ terminus of the oligonucleotide. These are then reacted to give the ligand‐oligonucleotide conjugate. ...