Now showing items 31-36 of 36
The half-life of 76 As
(Kluwer Academic Publishers; Kluwer Academic Publishers/Akadémiai Kiadó ; Springer Science+Business Media, 2003-09)
In the course of making high-accuracy measurements of arsenic, we found that the most recently published and compiled half-life of 76 As did not agree with our data as well as the earlier accepted value. To redetermine ...
A Phase I Clinical Trial of Spicamycin Derivative KRN5500 (NSC 650426) Using a Phase I Accelerated Titration “2B” Design
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-02)
The spicamycin derivative KRN5500 was considered as a potential anti-cancer agent based on in vitro and preclinical studies. A Phase I study involving 24 cancer patients in whom tumors were refractory to all other conventional ...
Enhanced sensitivity electrochemical assay of low-molecular-weight heparins using rotating polyion-sensitive membrane electrodes
(Springer-Verlag, 2003-11)
Use of a novel rotating polycation-sensitive polymer membrane electrode yields sensors that can serve as simple potentiometric titration endpoint detectors for the determination of three FDA approved low-molecular-weight ...
The role of DNA synthesis inhibition in the cytotoxicity of 2′,2′-difluoro-2′-deoxycytidine
(Springer-Verlag, 2003-10)
Cytotoxicity from the anticancer drug 2′,2′-difluoro-2′-deoxycytidine (dFdCyd) has been correlated with its incorporation into DNA. However, cytotoxicity may also result from inhibition of DNA synthesis, due to either (1) ...
Chemistry of CpG DNA
(Wiley Periodicals, Inc., 2003-03)
The vertebrate immune system can recognize specific pathogen‐associated molecular patterns in invading microorganisms, including the unmethylated CpG dinucleotide. This unit discusses the receptors that recognize CpG motifs ...
A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A 2 with ceramide transacylase activity
(Kluwer Academic Publishers; Springer Science+Business Media, 2003-01)
A series of inhibitors of glucosylceramide synthesis, the PDMP based family of compounds, has been developed as a tool for the study of sphingolipid biochemistry and biology. During the course of developing more active ...