Now showing items 11-19 of 19
Straying From the Beaten Path, and Other Stories About Molecules
(Kluwer Academic Publishers-Plenum Publishers; Springer Science + Business Media, Inc., 2005-02)
What determines a person’s course in life is to a great extent an accident. Even though my entry into the field of electron diffraction was largely a matter of chance, once in the field, I found it offered an extraordinary ...
Fluorinated α-aminophosphonates—a new type of irreversible inhibitors of serine hydrolases
(Nauka/Interperiodica; MAIK “Nauka/Interperiodica” ; Springer Science+Business Media, 2005-01)
Improved Electrochemical Analysis of Neuropathy Target Esterase Activity by a Tyrosinase Carbon Paste Electrode Modified by 1-Methoxyphenazine Methosulfate
(Kluwer Academic Publishers; Springer, 2005-08)
A graphite-paste tyrosinase biosensor was improved by adding 1-methoxyphenazine methosulfate as a mediator. Mediator modification enhanced sensitivity to phenol 4-fold and long-term stability 3-fold. Phenol could be detected ...
Phase II study of oral bis (aceto) ammine dichloro (cyclohexamine) platinum (IV) (JM-216, BMS-182751) given daily x 5 in hormone refractory prostate cancer (HRPC)
(Kluwer Academic Publishers; Springer Science+Business Media, 2005-01)
JM-216 is an orally bioavailable platinum compound with activity against many tumor models. The objective of this study was to determine the safety profile and anti-tumor activity of JM-216 in patients with hormone refractory ...
A Phase II study of celecoxib, gemcitabine, and cisplatin in advanced pancreatic cancer
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-12)
Background . Pancreatic cancer is amongst the most chemoresistant malignancies. Expression of the cyclooxygenase-2 (COX-2) enzyme plays a major role in tumor progression and resistance to therapy. A Phase II study was ...
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-08)
Purpose : Loss of PTEN, which is common in glioblastoma multiforme (GBM), results in activation of the mammalian target of rapapmycin (mTOR), thereby increasing mRNA translation of a number of key proteins required for ...
Phase II trial of fenretinide in advanced renal carcinoma
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-01)
Purpose : Fenretinide, a synthetic form of retinoid, induced apoptosis even in chemotherapy resistant cell lines. A phase II study was hence conducted to evaluate toxicity and efficacy of fenretinide in metastatic renal ...
A self-renewal assay for cancer stem cells
(Springer-Verlag, 2005-11)
Cancers of epithelial origin are responsible for the majority of cancer-related deaths in the USA. Unfortunately, although chemotherapy and/or radiation therapy can sometimes shrink tumors, metastatic cancers of epithelial ...