Now showing items 21-30 of 52
A CE assay for the detection of agonist-stimulated adenylyl cyclase activity
(WILEY-VCH Verlag, 2007-06)
A CE assay was developed for the detection of adenylyl cyclase (AC) activity stimulated at the AC and G protein-coupled receptor (GPCR) level. In the assay, cell membranes overexpressing GPCR and/or AC were incubated with ...
Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells
(WILEY-VCH Verlag, 2007-08)
The molecular chaperone heat shock protein 90 (Hsp90) affects the function of many oncogenic signaling proteins including nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressed in anaplastic large cell lymphoma (ALCL). ...
Proteomic profiling identifies breast tumor metastasis-associated factors in an isogenic model
(WILEY-VCH Verlag, 2007-01)
A combination of LC and MS was applied to an isogenic breast tumor metastasis model to identify proteins associated with a cellular phenotype. Chromatofocusing followed by nonporous-RP-HPLC/ESI-TOF MS was applied to cell ...
Mechanistic Analysis of Nucleophilic Substrates Oxidation by Functional Models of Vanadium-Dependent Haloperoxidases: A Density Functional Theory Study
(WILEY-VCH Verlag, 2007-02)
Density functional theory has been used to investigate the structural, electronic, and reactivity properties of an established functional model for vanadium-dependent haloperoxidases, K[VO(O 2 )Hheida] (Hheida 2– = ...
Future of biomedical sciences: Single molecule microscopy
(Wiley Subscription Services, Inc., A Wiley Company, 2007-02-05)
The behavior of single molecule defines whether a cell lives, dies, or responds to a specific drug treatment. Single molecule microscopies have begun to reveal the number, location, and functionalities of molecules outside ...
Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis
(Wiley Subscription Services, Inc., A Wiley Company, 2007-12-05)
Ribonuclease P (RNase P) is a ribonucleoprotein (RNP) complex that catalyzes the metal-dependent maturation of the 5′ end of precursor tRNAs (pre-tRNAs) in all organisms. RNase P is comprised of a catalytic RNA (P RNA), ...
Electrodeless direct current dielectrophoresis using reconfigurable field-shaping oil barriers
(WILEY-VCH Verlag, 2007-12)
We demonstrate dielectrophoretic (DEP) potential wells using pairs of insulating oil menisci to shape the DC electric field. These oil menisci are arranged in a configuration similar to the quadrupolar electrodes, typically ...
Effects of surface modification, carbon nanofiber concentration, and dispersion time on the mechanical properties of carbon-nanofiber–polycarbonate composites
(Wiley Subscription Services, Inc., A Wiley Company, 2007-03-15)
The time effect of ultrasonication was investigated for dispersing carbon nanofibers (CNFs) into a polycarbonate (PC) matrix on the mechanical properties of thus-produced composites. The effects of CNF surface modification ...
Assessing Guest Selectivity within Metallacrown Host Compartments
(WILEY-VCH Verlag, 2007-04)
15-MC-5 complexes associate in the solid state to form chiral compartments capable of binding guests. Using small molecular yardsticks, we are able to assess the size restrictions of these structures. Dicarboxylate guests ...
On the Mechanism of Energy Transfer in the Plasma-Propellant Interaction
(WILEY-VCH Verlag, 2007-10)
A coupled plasma sheath/ablation model is developed for electrothermal chemical gun applications. By combining a commonly employed collisional sheath model with a previous ablation model, the convective heat flux as a ...