Now showing items 21-30 of 37
A poke in the eye: Inhibiting HIV-1 protease through its flap-recognition pocket
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08)
A novel mechanism of inhibiting HIV-1 protease (HIVp) is presented. Using computational solvent mapping to identify complementary interactions and the Multiple Protein Structure method to incorporate protein flexibility, ...
Synthesis of Fe-MCM-41 from silatrane and FeCl 3 via sol–gel process and its epoxidation acivity
(John Wiley & Sons, Ltd., 2008-02)
An iron-containing mesoporous molecular sieve, or Fe-MCM-41, was successfully synthesized the via sol–gel technique using silatrane and FeCl 3 as the silicon and iron sources, and was characterized using various techniques. ...
Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: Accurate detection of CA19-9 levels in pancreatic cancer
(WILEY-VCH Verlag, 2008-08)
The current study analyzed reverse phase protein arrays (RPPA) as a means to experimentally validate biomarkers in blood samples. One microliter samples of sera ( n 14= 1471), and plasma ( n 14= 1478) were serially diluted ...
Multiplexed detection and applications for separations on parallel microchips
(WILEY-VCH Verlag, 2008-08)
Much work has been performed since the development of the lab-on-a-chip concept that has brought microfabricated systems to the forefront of bioanalytical research. The success of using these microchips for performing ...
Bicelle-Enabled Structural Studies on a Membrane-Associated Cytochrome 14b 5 by Solid-State MAS NMR Spectroscopy This study was supported by research funds from NIH (to A.R. and L.W.), the office of vice president for research (to A.R.), and a VA Merit Review grant to L.W. We thank the 900 MHz Facilities at East Lansing and Tallahassee. MAS=magic angle spinning.
(WILEY-VCH Verlag, 2008-09-29)
No Abstract
Synthesis, Crystal Structure and Thermal Reactivity of [ZnX 2 (2-chloropyrazine)] (X = Cl, Br, I) Coordination Compounds
(WILEY-VCH Verlag, 2008-02)
Reaction of zinc(II) halides with 2-chloropyrazine in different solvents leads to the formation of five new coordination compounds that contain either only 2-chloropyrazine or additional water molecules as donor ligands. ...
Amperometric Nitrosothiol Sensor Using Immobilized Organoditelluride Species as Selective Catalytic Layer
(WILEY-VCH Verlag, 2008-02)
A new amperometric sensor capable of responding to various biological S -nitrosothiol species (RSNOs) is described. The sensor is prepared using an organoditelluride-tethered poly(allyamine hydrochloride) (PAH) polymer ...
The Interdisciplinary Biophysics Graduate Program at the University of Michigan
(Wiley Subscription Services, Inc., A Wiley Company, 2008-04)
The Michigan Biophysics Graduate Program (MBGP) was established in 1949, making it one of the first such programs in the world. The intellectual base of the program was significantly broadened in the 1980 when faculty ...
Empirical entropic contributions in computational docking: Evaluation in APS reductase complexes
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08)
The results from reiterated docking experiments may be used to evaluate an empirical vibrational entropy of binding in ligand–protein complexes. We have tested several methods for evaluating the vibrational contribution ...
Characterization of Industrial and Biological Complex Fluids Using Confocal Microscopy.
(2008)
Complex fluids are materials that respond to applied stresses in a way that is
intermediate between that of a purely viscous fluid or a fully elastic solid. The
characterization of material properties depends upon the ...