Now showing items 911-920 of 959
Role of Proton-Coupled Oligopeptide Transporters in Small Peptide Absorption and Disposition.
(2009)
Proton-coupled oligopeptide transporters (POTs) (i.e., PEPT1, PEPT2, PHT1 and PHT2) translocate various small peptide/mimetic across the biological membrane. The first part of this dissertation focuses on investigating ...
Regulation of Dopamine Transporter Trafficking by Substrates, Rabs, and Shares.
(2009)
The plasmalemmal dopamine transporter (DAT) regulates dopaminergic neurotransmission by facilitating reuptake of extracellular dopamine (DA). The psychostimulant amphetamine (AMPH) is a substrate of DAT which stimulates ...
Medical Ultrasound Aberration Correction via Acoustic Droplet Vaporization and Time-Reversal Acoustics.
(2009)
Time-reversal acoustics (TRA) is an alternative to standard focusing approaches in medical ultrasound. TRA records backscattered ultrasound and time-reverses it (Ψ(t) -> Ψ(−t)). Due to the time-reversal invariance of the ...
In Silico Haplotyping, Genotyping and Analysis of Resequencing Data using Markov Models.
(2009)
Searches for the elusive genetic mechanisms underlying complex diseases have long challenged human geneticists. Recently, genome-wide association studies (GWAS) have successfully identified many complex disease susceptibility ...
Characterization of the Molecular Epidemiology of Neisseria meningitidis and Investigation of Two Potential Risk Factors Associated with Invasive Meningococcal Disease.
(2009)
The occurrence of invasive meningococcal disease (IMD) is the result of a complex interaction of host, agent, and environmental risk factors within both individuals and populations. The goal of this dissertation research ...
Enzyme Aging: Structural Insights from NTE and Patatin.
(2009)
Neuropathy target esterase (NTE) is an integral membrane protein whose covalent modification by organophosphorus compounds (OPs) results in a delayed axonopathy (called OP-induced delayed neuropathy (OPIDN)) whose mechanisms ...
The Human Gestational Membranes as a Site of Polybrominated Diphenyl Ether Toxicity.
(2009)
Preterm birth is a major public health concern impacting one in eight babies born in the U.S.A. Although a precise cause for preterm birth cannot be established in most cases, one of the most promising predictors of preterm ...
Physical Activity in Relation to Depressive Symptoms in Black U.S. Adults: Results from the National Survey of American Life.
(2009)
A report of the Surgeon General revealed Blacks are underrepresented in mental health research (USDHHS, 2001). The purpose of the current study is to investigate the relation between physical activity (PA) and depressive ...
Study of Women Veterans in Menopause.
(2009)
In healthy women, menopause symptoms have been associated with decreased quality of life, limitations in physical functioning and perceived declines in health status. Most menopause research is limited to the study of ...
Older Japanese Adults' Religiosity: Relationship with Age; Gender; Physical, Mental, and Cognitive Health; Subjective Feelings about Health; Social Support/Integration; and Health Promotion Behaviors.
(2009)
The purpose of this study was to identify predictors of older Japanese adults’ health promotion behaviors by examining relationships between their religiosity and age; gender; physical, mental, and cognitive health status; ...