Now showing items 11-20 of 50
A multiplexed bead assay for profiling glycosylation patterns on serum protein biomarkers of pancreatic cancer
(WILEY‐VCH Verlag, 2011-08)
A multiplexed bead‐based immunoassay was developed to simultaneously profile glycosylation patterns of serum proteins to investigate their usefulness as biomarkers for pancreatic cancer. The multiplex assay utilized ...
Free energy simulation to investigate the effect of amino acid sequence environment on the severity of osteogenesis imperfecta by glycine mutations in collagen
(Wiley Subscription Services, Inc., A Wiley Company, 2011-06)
Molecular dynamics simulations were carried out to calculate the free energy change difference of two collagen-like peptide models for Gly→Ser mutations causing two different osteogenesis imperfecta phenotypes. These ...
The Water Uptake of Plasticized Poly(vinyl chloride) Solid‐Contact Calcium‐Selective Electrodes
(WILEY‐VCH Verlag, 2011-09)
A hyphenated method based on FTIR‐ATR and electrochemical impedance spectroscopy has been applied to simultaneously measure the water uptake, changes in the bulk resistance and potential of plasticized poly(vinyl chloride) ...
Differential profiling studies of N‐linked glycoproteins in glioblastoma cancer stem cells upon treatment with γ‐secretase inhibitor
(WILEY‐VCH Verlag, 2011-10)
We have recently demonstrated that Notch pathway blockade by γ‐secretase inhibitor (GSI) depletes cancer stem cells (CSCs) in Glioblastoma Multiforme (GBM) through reduced proliferation and induced apoptosis. However, the ...
Crystal Structure, Charge Transport, and Magnetic Properties of MnSb 2 Se 4
(WILEY‐VCH Verlag, 2011-09)
A single phase of MnSb 2 Se 4 was synthesized by combining high‐purity elements at 773 K. Single‐crystal X‐ray diffraction revealed that MnSb 2 Se 4 is isostructural with FeSb 2 Se 4 crystallizing in the monoclinic space ...
Abacus: A computational tool for extracting and pre-processing spectral count data for label-free quantitative proteomic analysis
(WILEY-VCH Verlag, 2011-04)
We describe Abacus, a computational tool for extracting spectral counts from MS/MS data sets. The program aggregates data from multiple experiments, adjusts spectral counts to accurately account for peptides shared across ...
Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
(WILEY-VCH Verlag, 2011-04)
Affinity purification coupled to mass spectrometry (AP-MS) represents a powerful and proven approach for the analysis of protein–protein interactions. However, the detection of true interactions for proteins that are ...
Dose‐dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ‐secretase inhibitor
(WILEY‐VCH Verlag, 2011-12)
Notch signaling has been demonstrated to have a central role in glioblastoma (GBM) cancer stem cells (CSCs) and we have demonstrated recently that Notch pathway blockade by γ‐secretase inhibitor (GSI) depletes GBM CSCs and ...
How microbial proteomics got started
(WILEY‐VCH Verlag, 2011-08)
Publication in 1975 by Patrick O'Farrell of a procedure to separate the proteins of Escherichia coli in a two‐dimensional array on polyacrylamide gels marked the birth of the field now called proteomics. Although O'Farrell's ...