Now showing items 991-1000 of 1006
Exploiting the Bioenergetics of Disease-Causing Lymphocytes for Selective Immunomodulation.
(2012)
In diseases such as lupus or graft-versus-host disease (GVHD), lymphocytes react against self- or allo-antigen and mediate tissue damage. Current treatments for such diseases rely on non-specific immunosuppression and ...
Chaperone-dependent Ubiquitination of Neuronal Nitric Oxide Synthase.
(2012)
Nitric oxide synthase (NOS), a cytochrome P450-like hemoprotein enzyme, catalyzes the synthesis of nitric oxide, a critical signaling molecule in a variety of physiological processes. Our lab has found that certain drugs, ...
Biochemical and Structural Analyses of Budding Yeast Telomere Associated CST Complex
(2012)
Telomeres are specialized protein-DNA complexes that compose the natural termini of linear chromosomes. Telomeres prevent chromosome ends from deleterious degradation and fusion events and ensure the complete replication ...
Interactions between Neuronal Innate Immune Pattern Recognition Receptor Pathways and Neurotropic Arboviruses: Host Measures, Viral Countermeasures, and Potential Therapeutics.
(2012)
Neurotropic arboviruses are a group of pathogens capable of causing severe and fatal central nervous system infections for which there are few effective treatments or vaccines. The extent of neurotropic arbovirus-mediated ...
Structure Based Design of Peptidomimetic Inhibitors of the MLL1-WDR5 Interaction.
(2012)
MLL1 is a histone-3 lysine-4 (H3K4) methyltransferase, which is misregulated in patients with leukemia and linked with tumorigenicity through upregulation of the target genes HoxA9 and Meis-1. Suppressing expression of ...
Exploring and Exploiting DNA Repair Mechanisms to Improve Suicide Gene Therapy with Ganciclovir.
(2012)
Exploring the unique mechanisms of anticancer drugs can provide the opportunity to identify novel targets for future drug development. Suicide gene therapy with the herpes simplex virus thymidine kinase (HSV-TK) and ...
Investigating the Role of HIP1/PDGFβR in Leukemogenesis and Imatinib Sensitivity
(2012)
The Huntingtin interacting protein 1 (HIP1)-platelet-derived growth factor beta receptor (PDGFβR) fusion oncogene (H/P), resulting from a somatic t(5;7) translocation, causes expression of a constitutively active tyrosine ...
The Effect of Migration on Cognitive Representations, Blood Pressure Level and Dietary Habits in African Immigrant Women.
(2012)
Migration has been associated with increased risk of hypertension through stressors associated with cultural change and health behavior. Like other immigrants, women arriving in the U.S. in good health have experienced ...
Linkages Between Extreme Precipitation, Water Quality, and Gastrointestinal Illness.
(2012)
Background: The frequency, intensity, and duration of extreme weather events are expected to increase based on current climate model projections. Such changes, particularly those associated with extreme precipitation, will ...
LINE-1 Retrotransposition in Human Genomic Variation.
(2012)
Long interspersed element-1 (LINE-1 or L1) is a ubiquitous mobile element in mammalian genomes. There are ~500,000 copies of L1 throughout the human genome, comprising ~17% of our DNA. Interestingly, though the majority ...