Now showing items 21-24 of 24
Characterization of the Membrane-Bound Full-Length Complex between Cytochrome b5 and Cytochrome P450 2B4.
(2013)
While cyt b5 has been shown to be an essential part of the catalytic cycle of cyt P450 in vivo, very little is known about its membrane-bound full-length structure and its ability to form complexes with cyt P450 in the ...
Understanding Pre-mRNA Dynamics in Single Spliceosome Complexes.
(2013)
The spliceosome is a large RNA-protein complex that catalyzes pre-mRNA splicing by removing sequences called introns and joining of the remaining sequences, called exons, to produce a mature mRNA. Despite over a quarter ...
Molecular Recognition of Inhibitors, Metal Ions and Substrates by Ribonuclease P.
(2013)
Ribonuclease P (RNase P) is a divalent metal ion-dependent endonuclease that catalyzes cleavage of the 5’ leader of precursor transfer RNA (pre-tRNA), an essential tRNA processing step in all domains of life. Bacterial ...
Incorporation of Protein Flexibility in Structure-Based Drug Discovery of HIV-1 Protease and Bacterial Hsp70 Chaperone.
(2013)
Damm et al. utilized a multiple protein structure (MPS)-based method and discovery an allosteric site of HIV-1 protease (HIV-1p) that had not been described before. Based on this new site, a MPS-based pharmacophore model ...