Now showing items 11-16 of 16
Mapping, Tracking and Modeling the Movements of Single Membrane-Bound Transcription Activator Proteins in Live Vibrio cholerae.
(2014)
Cholera has been known since ancient times, yet there is still no cure. Vibrio cholerae bacteria cause cholera by producing cholera toxin. Cholera toxin production is regulated by the protein ToxT, which itself is regulated ...
A Tale of Two RNAs: Single Molecule Investigation of the Conformation, Dynamics and Ligand Binding to the PreQ1 and T-box Riboswitches.
(2014)
Riboswitches are structured mRNA domains that can bind cellular metabolites and control gene expression of downstream genes mainly via transcription attenuation or inhibition of translation initiation. Although structures ...
Synthesis and Biochemical Evaluation of Multifunctional Acetylcholinesterase Inhibitor Hybrids for Treatment of Alzheimer's Disease.
(2014)
Alzheimer’s disease (AD) places a significant and dramatically increasing burden on society. While pathological hallmarks of this neurodegenerative disorder are known, the exact cause remains unclear. Acetylcholinesterase ...
Structure-Based Design, Synthesis and Evaluation of Novel and Selective Small-Molecule Inhibitors of the Anti-Apoptotic Protein Mcl-1.
(2014)
The mitochondrial pathway to apoptosis is regulated through the protein-protein interactions of pro- and anti-apoptotic members of Bcl-2 family proteins. Overexpression of the anti-apoptotic members such as Mcl-1, Bcl-2 ...
Structures, Dynamics, and Ribozymes: An Investigation of RNA Structural Dynamics with the Hepatitis Delta Virus and Hairpin Ribozymes.
(2014)
The function of catalytic ribonucleic acid (RNA), or ribozymes, depends on the structural dynamics of the molecule. Although the main function of RNA was once thought to be mainly in the production of proteins, it is now ...
Molecular Interactions between Various Model Cell Membranes and Membrane Active Peptides Studied by Sum Frequency Generation Vibrational Spectroscopy.
(2014)
Since the use of native cell membranes for biophysical studies is difficult, membrane mimetics are often used. However, if the model membrane is too simple, it may not be able to provide physiologically meaningful information. ...