Now showing items 21-30 of 44
Substrate Activity Screening with Kinases: Discovery of Small‐Molecule Substrate‐Competitive c‐Src Inhibitors
(WILEY‐VCH Verlag, 2014-07-01)
Substrate‐competitive kinase inhibitors represent a promising class of kinase inhibitors, however, there is no methodology to selectively identify this type of inhibitor. Substrate activity screening was applied to tyrosine ...
Sequence context and crosslinking mechanism affect the efficiency of in vivo capture of a protein–protein interaction
(Wiley Periodicals, Inc., 2014-04)
Protein–protein interactions (PPIs) are essential for implementing cellular processes and thus methods for the discovery and study of PPIs are highly desirable. An emerging method for capturing PPIs in their native cellular ...
Orthogonal surface functionalization through bioactive vapor‐based polymer coatings
(Academic PressWiley Periodicals, Inc., 2014-07-15)
Reactive chemical vapor deposition (CVD) polymerization provides a substrate‐independent platform for effective functionalization of virtually any solid substrates, flat, or curved, even with complex geometries. This article ...
Tailoring Intermolecular Interactions for Efficient Room‐Temperature Phosphorescence from Purely Organic Materials in Amorphous Polymer Matrices
(WILEY‐VCH Verlag, 2014-10-13)
Herein we report a rational design strategy for tailoring intermolecular interactions to enhance room‐temperature phosphorescence from purely organic materials in amorphous matrices at ambient conditions. The built‐in ...
Synthesis and On‐Demand Gelation of Multifunctional Poly(ethylene glycol)‐Based Polymers
(Wiley Periodicals, Inc., 2014-04)
Revisiting the identification of canonical splice isoforms through integration of functional genomics and proteomics evidence
(Wiley Periodicals, Inc., 2014-12)
Collisional and Coulombic Unfolding of Gas‐Phase Proteins: High Correlation to Their Domain Structures in Solution
(WILEY‐VCH Verlag, 2014-08-25)
The three‐dimensional structures adopted by proteins are predicated by their many biological functions. Mass spectrometry has played a rapidly expanding role in protein structure discovery, enabling the generation of models ...
1958 – 2014: nach 56 Jahren Forschung endlich eine Erklärung für die Reaktivität von Cytochrom P450
(WILEY‐VCH Verlag, 2014-05-05)