Now showing items 711-716 of 716
Role of Diet in Heavy Metal Exposure and Toxicity during Prenatal and Peripubertal Periods
(2016)
Nutrition is a valuable consideration in environmental risk assessment, given the interaction of nutrients with toxicants at source, body burden, and health effect. Heavy metal toxicants – cadmium and lead – can be introduced ...
Development and Characterization of Novel Mcl-1 Inhibitors for Treatment of Cancer.
(2016)
Myeloid cell leukemia-1 (Mcl-1) is a potent anti-apoptotic protein, member of the anti-apoptotic Bcl-2 family. Overexpression of Mcl-1 is associated with high tumor grade, resistance to chemotherapy, and poor prognosis in ...
Dopamine Contributions to Motivational Vigor and Reinforcement Driven Learning.
(2016)
Brain mechanisms for reinforcement learning and adaptive decision-making are widely accepted to critically involve the basal ganglia (BG) and the neurotransmitter dopamine (DA). DA is a key modulator of synaptic plasticity ...
To Be, or Not to Be: Cellular Homeostasis to Mechanical Perturbations
(2016)
Mechanical homeostasis is an emerging mechanobiology concept that describes the critical biological process to maintain whole-cell/tissue physiology against forces and deformation arising both intra- and extracellularly. ...
Bridge Employment and Health.
(2016)
Due to the increasing longevity, advancing yet skyrocketing health care costs, and the lack of funds for elderly welfare, post-retirement health among older adults has become a crucial issue both at the individual and ...
A Poised Negative Feedback Circuit Balances Continual Self-Renewal with Rapid Restriction of Developmental Potential across Asymmetric Stem Cell Division.
(2016)
The identities of stem cells and their differentiated progeny are controlled by transcription factor networks that interact with chromatin modifying enzymes to package the genome into active and repressed domains. These ...